ArticleFrontiers in microbiology2017
Oropharyngeal and Sputum Microbiomes Are Similar Following Exacerbation of Chronic Obstructive Pulmonary Disease.
Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Multi-site microbiomes' response to chronic obstructive pulmonary disease.Microbiology spectrum · 2026Article
- Benefits and challenges of host depletion methods in profiling the upper and lower respiratory microbiome.NPJ biofilms and microbiomes · 2025Article
- Genetic Concordance of Staphylococcus aureus From Oropharyngeal and Sputum Cultures in People With Cystic Fibrosis.Pediatric pulmonology · 2025Article
- Oropharyngeal microbiome profiling and its association with age and heart failure in the elderly population from the northernmost province of China.Microbiology spectrum · 2024Article
- The nasal microbiota is a potential diagnostic biomarker for sepsis in critical care units.Microbiology spectrum · 2024Article
- Oropharyngeal microbial ecosystem perturbations influence the risk for acute respiratory infections in common variable immunodeficiency.Frontiers in immunology · 2024Article
- ClinicalJournal of fungi (Basel, Switzerland) · 2022Review
- The Airway Microbiota Signatures of Infection and Rejection in Lung Transplant Recipients.Microbiology spectrum · 2022Article
- A longitudinal study of the pulmonary mycobiome in subjects with and without chronic obstructive pulmonary disease.PloS one · 2022Article
- Respiratory microbiome in mechanically ventilated patients: a narrative review.Intensive care medicine · 2021Review
- Prevalence and antimicrobial resistance profiles of respiratory microbial flora in African children with HIV-associated chronic lung disease.BMC infectious diseases · 2021Article
- The sputum microbiome associated with different sub-types of AECOPD in a Chinese cohort.BMC infectious diseases · 2020Article
- Perspectives in lung microbiome research.Current opinion in microbiology · 2020Review
- Vital Members in the More Dysbiotic Oropharyngeal Microbiotas in H7N9-Infected Patients.Frontiers in medicine · 2020Article
- Septic patients in the intensive care unit present different nasal microbiotas.Future microbiology · 2019Article
- Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner.PloS one · 2019Article
- Oropharyngeal Microbiota in Frail Older Patients Unaffected by Time in Hospital.Frontiers in cellular and infection microbiology · 2018Article
- Moderate-Intensity Exercise Affects Gut Microbiome Composition and Influences Cardiac Function in Myocardial Infarction Mice.Frontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growing evidence suggests that the airway microbiota might be involved in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Understanding this relationship requires examination of a large-scale population for a long duration to accurately monitor changes in the microbiome. This type of longitudinal study requires an appropriate sampling strategy; two options are the collection of sputum or oropharyngeal swabs. Comparative analysis of the changes that occur in these two specimen types has not been previously performed. This observational study was conducted to explore oropharyngeal microbial community dynamics over time and to examine the relationship between oropharyngeal swabs and sputum. A total of 114 samples were collected from four patients suffering from severe AECOPD. Bacterial and fungal communities were evaluated using 16S rRNA and ITS sequencing. Inter-individual differences were found in bacterial community structure, but the core genera were shared by both sample types and included 32 lineages. Most of the core genera were members of the phyla Proteobacteria, Firmicutes and Ascomycota. Although the oropharyngeal samples showed higher bacterial alpha diversity, the two sample types generated rather similar taxonomic profiles. These results suggest that the sputum microbiome is remarkably similar to the oropharyngeal microbiome. Thus, oropharyngeal swabs can potentially be used instead of sputum samples for patients with exacerbation of COPD.
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