ReviewProgress in neuro-psychopharmacology & biological psychiatry2018
Prefrontal cortex executive processes affected by stress in health and disease.
Review in Progress in neuro-psychopharmacology & biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Regulatory Role of PFC Corticotropin-Releasing Factor System in Stress-Associated Depression Disorders: A Systematic Review.Cellular and molecular neurobiology · 2023Pooled it
- Cognitive impairments associated with chemotherapy in women with breast cancer: a meta-analysis and meta-regression.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Pooled it
- Efficacy and safety of ashwagandha root extract in children and adolescents with mild attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled trial.Journal of medicine and life · 2026Trial
- Hypnosis reshapes multilevel stress response and enhances executive performance in stressed medical students.Scientific reports · 2026Trial
- Probiotics-induced changes in gut microbial composition and its effects on cognitive performance after stress: exploratory analyses.Translational psychiatry · 2021Trial
- Blunted diurnal cortisol slope as a risk marker for 9-year executive function decline: amplification by daily stress and worry severity.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- The role of microRNAs in executive functions: a comprehensive review and bioinformatics analysis of human and animal studies.Molecular psychiatry · 2026Review
- Signaling Under Stress: Targeting the Glucocorticoid Receptor in Cancer.Cancer research · 2026Review
- Association of short-term ambient environmental exposures with suicide and drug overdose deaths among U.S. veterans.American journal of epidemiology · 2026Article
- Targeting insulo-frontal pathway to reduce stress-evoked cognitive rigidity.Nature communications · 2026Article
- Cyber-victimized and cognitively fogged? Cyberbullying victimization and executive function.BMC public health · 2026Article
- Homo sapiens, industrialisation and the environmental mismatch hypothesis.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression.Journal of neurochemistry · 2026Review
- TARGETING INSULO-FRONTAL PATHWAY TO REDUCE STRESS-EVOKED COGNITIVE RIGIDITY.bioRxiv : the preprint server for biology · 2026Article
- Enhancing Upper Secondary Students' Situational Engagement and Cognitive Prerequisites of Learning Through the Physically Active Academic Lessons Intervention: Protocol for a Mixed Methods Cluster Randomized Individual Crossover Trial.JMIR research protocols · 2026Article
- Neural mechanisms underlying cognitive inflexibility in obsessive-compulsive disorder: a review.Frontiers in psychiatry · 2026Review
- Differences in brain functioning between obsessive-compulsive disorder and generalized anxiety disorder: a clinical study using functional near-infrared spectroscopy.Frontiers in psychiatry · 2026Article
- Exercise intervention for rumination: from neural mechanisms to clinical applications.Frontiers in psychology · 2026Review
- From stress to success: using physiological data to predict cardiopulmonary resuscitation simulation performance.Frontiers in psychology · 2026Article
- Inflammatory mechanisms contribute to long-term cognitive deficits induced by perinatal asphyxia via interleukin-1.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Prefrontal cortical executive functions comprise a number of cognitive capabilities necessary for goal directed behavior and adaptation to a changing environment. Executive dysfunction that leads to maladaptive behavior and is a symptom of psychiatric pathology can be instigated or exacerbated by stress. In this review we survey research addressing the impact of stress on executive function, with specific focus on working memory, attention, response inhibition, and cognitive flexibility. We then consider the neurochemical pathways underlying these cognitive capabilities and, where known, how stress alters them. Finally, we review work exploring potential pharmacological and non-pharmacological approaches that can ameliorate deficits in executive function. Both preclinical and clinical literature indicates that chronic stress negatively affects executive function. Although some of the circuitry and neurochemical processes underlying executive function have been characterized, a great deal is still unknown regarding how stress affects these processes. Additional work focusing on this question is needed in order to make progress on developing interventions that ameliorate executive dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.