ArticleCell2017
Distinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression.
Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
155 citing papers in PubMed, 2 syntheses or guidelines pooled it, 283 citations in OpenAlex.
- The disappointment centre of the brain gets exciting: a systematic review of habenula dysfunction in depression.Translational psychiatry · 2024Pooled it
- Response Flexibility: The Role of the Lateral Habenula.Frontiers in behavioral neuroscience · 2022Pooled it
- G protein-coupled receptor 75 mediates depression-like behaviors and HPA axis hyperactivity through an excitatory arcuate-paraventricular nucleus circuit.Acta pharmacologica Sinica · 2026Article
- Dynamic Repertoire of Brain Networks in Mindfulness-Based Cognitive Therapy During Rumination: A Randomized Controlled Trial.Biological psychiatry global open science · 2026Article
- Adolescent social isolation promotes oxycodone consumption and augments mu opioid receptor responsiveness in the ventral pallidum.Addiction neuroscience · 2026Article
- Unpacking Ventral Pallidum GABA Neuron Contributions to Opioid Drug Reward in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Molecular and neural circuit mechanisms of parvalbumin (PV) neurons in depression: Insights and advances.iScience · 2026Review
- Abnormal structural connectivity-functional connectivity coupling beyond the cortex in patients with chronic migraine.The journal of headache and pain · 2026Article
- MeCP2 regulates cell-type-specific functions of depressive-like symptoms in the nucleus accumbens.Experimental & molecular medicine · 2026Article
- The ventral hippocampus to paraventricular thalamus circuit regulates context-dependent hyperlocomotion through PAC1 receptor signaling in the chronic stress-induced PTSD mouse model.Translational psychiatry · 2026Article
- Most Ventral Pallidal Cholinergic Neurons Are Bursting Basal Forebrain Cholinergic Neurons with Mesocorticolimbic Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Complementary cortical and thalamic contributions to cell type-specific striatal activity dynamics during movement.Science advances · 2026Article
- Ventral pallidal perineuronal nets regulate opioid relapse.bioRxiv : the preprint server for biology · 2026Article
- Exercise-induced attenuation of the lateral habenula: a multi-axial quantitative synthesis of circuit-level resilience in depression.Frontiers in psychiatry · 2026Article
- Single-cell sequencing of rodent ventral pallidum reveals diverse neuronal subtypes with noncanonical interregional continuity.Science advances · 2025Article
- Paraventricular thalamic inputs to the ventral pallidum shape reward seeking during threat and fear responding in extinction.Behavioral neuroscience · 2025Article
- Ventral pallidum efferent pathways via mediodorsal thalamus and lateral habenula mediate default mode network regulation.iScience · 2025Article
- Thalamo-hippocampal pathway determines aggression and self-harm.Science advances · 2025Article
- Article
- Untangling the multifaceted VTA responses to stress.Trends in neurosciences · 2025Review
95 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Major depressive disorder (MDD) patients display a common but often variable set of symptoms making successful, sustained treatment difficult to achieve. Separate depressive symptoms may be encoded by differential changes in distinct circuits in the brain, yet how discrete circuits underlie behavioral subsets of depression and how they adapt in response to stress has not been addressed. We identify two discrete circuits of parvalbumin-positive (PV) neurons in the ventral pallidum (VP) projecting to either the lateral habenula or ventral tegmental area contributing to depression. We find that these populations undergo different electrophysiological adaptations in response to social defeat stress, which are normalized by antidepressant treatment. Furthermore, manipulation of each population mediates either social withdrawal or behavioral despair, but not both. We propose that distinct components of the VP PV circuit can subserve related, yet separate depressive-like phenotypes in mice, which could ultimately provide a platform for symptom-specific treatments of depression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.