Evidence map›Paper›PMID 28689506›Full record

ArticleEpidemiology and infection2017

Description and validation of a new automated surveillance system for Clostridium difficile in Denmark.

M Chaine, S Gubbels, M Voldstedlund, B Kristensen, J Nielsen, L P Andersen, S Ellermann-Eriksen, J Engberg, A Holm, B Olesen and 4 more

Registry-linked trialAbstract readValidation Study
In one paragraph

Article in Epidemiology and infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05932823 (Airflow and Hip Prosthesis Infections), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05932823 completednot on this map

Airflow and Hip Prosthesis Infections: A Registry Study Comparing Laminar vs. Turbulent Flow in the Danish Hip Arthroplasty Register.

Typeobservational_patient_registrySponsorUniversity Hospital Bispebjerg and FrederiksbergRan2010 to 2021Enrolled110,000ConditionsHip Prosthesis InfectionArmsLaminary airflow
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025
    Article
  2. Article
  3. The accuracy of fully automated algorithms for surveillance of healthcare-onsetAntimicrobial stewardship & healthcare epidemiology : ASHE · 2022
    Article
  4. Automated digital reporting of clinical laboratory information to national public health surveillance systems, results of a EU/EEA survey, 2018.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020
    Article
  5. The Economic Burden ofFrontiers in public health · 2020
    Article
  6. Incidence Rates and Risk Factors ofOpen forum infectious diseases · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

M ChaineDepartment of Infectious Disease Epidemiology and Prevention,Statens Serum Institut,Copenhagen,Denmark.
S GubbelsDepartment of Infectious Disease Epidemiology and Prevention,Statens Serum Institut,Copenhagen,Denmark.
M VoldstedlundDepartment of Infectious Disease Epidemiology and Prevention,Statens Serum Institut,Copenhagen,Denmark.
B KristensenDepartment of Infectious Disease Epidemiology and Prevention,Statens Serum Institut,Copenhagen,Denmark.
J NielsenDepartment of Infectious Disease Epidemiology and Prevention,Statens Serum Institut,Copenhagen,Denmark.
L P AndersenDepartment of Clinical Microbiology,Rigshospitalet,Copenhagen,Denmark.
S Ellermann-EriksenDepartment of Clinical Microbiology,Aarhus University Hospital,Aarhus,Denmark.
J EngbergDepartment of Clinical Microbiology,Slagelse Hospital,Slagelse,Denmark.
A HolmDepartment of Clinical Microbiology,Odense University Hospital,Odense,Denmark.
B OlesenDepartment of Clinical Microbiology,Herlev and Gentofte Hospital,Copenhagen,Denmark.
H C SchønheyderDepartment of Clinical Microbiology,Aalborg University Hospital,Aalborg,Denmark.
C ØstergaardDepartment of Clinical Microbiology,Hvidovre Hospital,Hvidovre,Denmark.
S EthelbergDepartment of Infectious Disease Epidemiology and Prevention,Statens Serum Institut,Copenhagen,Denmark.
K MølbakDivision of Infectious Disease Preparedness,Statens Serum Institut,Copenhagen,Denmark.ORCID 0000-0002-3100-4990

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The surveillance of Clostridium difficile (CD) in Denmark consists of laboratory based data from Departments of Clinical Microbiology (DCMs) sent to the National Registry of Enteric Pathogens (NREP). We validated a new surveillance system for CD based on the Danish Microbiology Database (MiBa). MiBa automatically collects microbiological test results from all Danish DCMs. We built an algorithm to identify positive test results for CD recorded in MiBa. A CD case was defined as a person with a positive culture for CD or PCR detection of toxin A and/or B and/or binary toxin. We compared CD cases identified through the MiBa-based surveillance with those reported to NREP and locally in five DCMs representing different Danish regions. During 2010-2014, NREP reported 13 896 CD cases, and the MiBa-based surveillance 21 252 CD cases. There was a 99·9% concordance between the local datasets and the MiBa-based surveillance. Surveillance based on MiBa was superior to the current surveillance system, and the findings show that the number of CD cases in Denmark hitherto has been under-reported. There were only minor differences between local data and the MiBa-based surveillance, showing the completeness and validity of CD data in MiBa. This nationwide electronic system can greatly strengthen surveillance and research in various applications.

Indexed as

Epidemiological MonitoringClostridioides difficileClostridium InfectionsColony Count, MicrobialDenmarkEnterocolitis, PseudomembranousHumansPolymerase Chain ReactionPopulation SurveillanceClostridium difficilegastrointestinal infectionshospital-acquired (nosocomial) infectionssurveillance system

Identifiers

PMID28689506
PMCPMC9148787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.