Evidence map›Paper›PMID 28689495›Full record

ArticleBMC psychiatry2017

Machine learning methods to predict child posttraumatic stress: a proof of concept study.

Glenn N Saxe, Sisi Ma, Jiwen Ren, Constantin Aliferis

Abstract read
In one paragraph

Article in BMC psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Glenn N SaxeDepartment of Child and Adolescent Psychiatry, New York University School of Medicine, One Park Avenue, New York, NY, 10016, USA. Glenn.Saxe@nyumc.org.
Sisi MaInstitute for Health Informatics and Department of Medicine, University of Minnesota, 330 Diehl Hall, MMC912, 420 Delaware Street S.E, Minneapolis, Minnesota, Mpls, MN, 55455, USA.
Jiwen RenDepartment of Child and Adolescent Psychiatry and Center for Health Informatics and Bioinformatics, New York University School of Medicine, One Park Avenue, New York, NY, 10016, USA.
Constantin AliferisInstitute for Health Informatics, Department of Medicine, and Data Science Program, University of Minnesota, Minneapolis, MN, USA.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
PTSD in Children with Injuries: A Longitudinal StudyR01MH063247 · NIMH · BOSTON MEDICAL CENTER · PI SAXE, GLENN N · 2003 to 2007
$1.9M
Network Science Methodology for Assessing PTSD RiskR21MH086309 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SAXE, GLENN N · 2009 to 2010
$443k
NCATS NIH HHS UL1 TR000114NIMH NIH HHS R01 MH063247NIMH NIH HHS R21 MH086309
6 · The paper itself

Abstract

backgroundThe care of traumatized children would benefit significantly from accurate predictive models for Posttraumatic Stress Disorder (PTSD), using information available around the time of trauma. Machine Learning (ML) computational methods have yielded strong results in recent applications across many diseases and data types, yet they have not been previously applied to childhood PTSD. Since these methods have not been applied to this complex and debilitating disorder, there is a great deal that remains to be learned about their application. The first step is to prove the concept: Can ML methods - as applied in other fields - produce predictive classification models for childhood PTSD? Additionally, we seek to determine if specific variables can be identified - from the aforementioned predictive classification models - with putative causal relations to PTSD.

methodsML predictive classification methods - with causal discovery feature selection - were applied to a data set of 163 children hospitalized with an injury and PTSD was determined three months after hospital discharge. At the time of hospitalization, 105 risk factor variables were collected spanning a range of biopsychosocial domains.

resultsSeven percent of subjects had a high level of PTSD symptoms. A predictive classification model was discovered with significant predictive accuracy. A predictive model constructed based on subsets of potentially causally relevant features achieves similar predictivity compared to the best predictive model constructed with all variables. Causal Discovery feature selection methods identified 58 variables of which 10 were identified as most stable.

conclusionsIn this first proof-of-concept application of ML methods to predict childhood Posttraumatic Stress we were able to determine both predictive classification models for childhood PTSD and identify several causal variables. This set of techniques has great potential for enhancing the methodological toolkit in the field and future studies should seek to replicate, refine, and extend the results produced in this study.

Indexed as

Machine LearningProof of Concept StudyArtificial IntelligenceChildChild, PreschoolFemaleHumansMaleRisk FactorsStress Disorders, Post-TraumaticChild & Adolescent psychiatryInformaticsMachine learningPTSDTraumatic stress

Identifiers

PMID28689495
PMCPMC5502325

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.