Evidence map›Paper›PMID 28689401›Full record

ArticleBiochemistry2017

Hole Hopping through Tryptophan in Cytochrome P450.

Maraia E Ener, Harry B Gray, Jay R Winkler

Abstract read
In one paragraph

Article in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Oxidizable amino acids around cytochrome P450 hemes.Journal of inorganic biochemistry · 2026
    Article
  2. Article
  3. Article
  4. Control of protein activity by photoinduced spin polarized charge reorganization.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  5. Review
  6. Oxalate decarboxylase uses electron hole hopping for catalysis.The Journal of biological chemistry · 2021
    Article
  7. Review
  8. Article
  9. Hole Hopping through Cytochrome P450.The journal of physical chemistry. B · 2020
    Article
  10. Mapping hole hopping escape routes in proteins.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  11. Effect of Crotalus basiliscus snake venom on the redox reaction of myoglobin.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2019
    Article
  12. Living with Oxygen.Accounts of chemical research · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Maraia E EnerBeckman Institute, California Institute of Technology , Pasadena, California 91125, United States.
Harry B GrayBeckman Institute, California Institute of Technology , Pasadena, California 91125, United States.
Jay R WinklerBeckman Institute, California Institute of Technology , Pasadena, California 91125, United States.ORCID 0000-0002-4453-9716
California Institute of Technology · US

Funding

ELECTRON-TRANSFER PROCESSES IN IRON AND COPPER PROTEINSR01DK019038 · NIDDK · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GRAY, HARRY B, WINKLER, JAY R · 1986 to 2023
$7.0M
NIDDK NIH HHS R01 DK019038
6 · The paper itself

Abstract

Electron-transfer kinetics have been measured in four conjugates of cytochrome P450 with surface-bound Ru-photosensitizers. The conjugates are constructed with enzymes from Bacillus megaterium (CYP102A1) and Sulfolobus acidocaldarius (CYP119). A W96 residue lies in the path between Ru and the heme in CYP102A1, whereas H76 is present at the analogous location in CYP119. Two additional conjugates have been prepared with (CYP102A1)W96H and (CYP119)H76W mutant enzymes. Heme oxidation by photochemically generated Ru

Indexed as

Archaeal ProteinsBacillus megateriumBacterial ProteinsCytochrome P-450 Enzyme SystemElectron TransportHemeModels, MolecularNADPH-Ferrihemoprotein ReductaseOxidation-ReductionPhotosensitizing AgentsRutheniumSulfolobus acidocaldariusTryptophanArchaeal ProteinsBacterial ProteinsCYP119 protein, Sulfolobus solfataricusCytochrome P-450 Enzyme Systemflavocytochrome P450 BM3 monoxygenasesHemeNADPH-Ferrihemoprotein ReductasePhotosensitizing AgentsRutheniumTryptophan

Identifiers

PMID28689401
PMCPMC5518273
OpenAlexW2727169426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.