Evidence map›Paper›PMID 28689329›Full record

ArticleJournal of autism and developmental disorders2017

Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety.

John D Herrington, Brenna B Maddox, Connor M Kerns, Keiran Rump, Julie A Worley, Jennifer C Bush, Alana J McVey, Robert T Schultz, Judith S Miller

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Forensic neuroimaging in childhood abduction, rape and murder case and trial outcome.Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2026
    Article
  5. Article
  6. Benign External Hydrocephalus in a Subgroup of Autistic Children Prior to Autism Diagnosis.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  7. Article
  8. Article
  9. Sensory Processing and Anxiety: Within and Beyond the Autism Spectrum.Current topics in behavioral neurosciences · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Examining Associations Between Amygdala Volumes and Anxiety Symptoms in Autism Spectrum Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

John D HerringtonCenter for Autism Research, The Children's Hospital of Philadelphia, 3535 Market Street, Suite 860, Philadelphia, PA, 19104, USA. herringtonj@email.chop.edu.
Brenna B MaddoxCenter for Autism Research, The Children's Hospital of Philadelphia, 3535 Market Street, Suite 860, Philadelphia, PA, 19104, USA.
Connor M KernsAJ Drexel Autism Institute & Community Health & Prevention, School of Public Health, Drexel University, 3020 Market Street, Suite 560, Philadelphia, PA, 19104, USA.
Keiran RumpDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Philadelphia, PA, 19104, USA.
Julie A WorleySPIN Inc, 10521 Drummond Street, Philadelphia, PA, 19154, USA.
Jennifer C BushDepartment of Psychological and Brain Sciences, Indiana University, 1101 E. 10th Street, Bloomington, IN, 47405, USA.
Alana J McVeyDepartment of Psychology, Marquette University, PO Box 1881, Milwaukee, WI, 53233, USA.
Robert T SchultzCenter for Autism Research, The Children's Hospital of Philadelphia, 3535 Market Street, Suite 860, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0002-9720-3917
Judith S MillerCenter for Autism Research, The Children's Hospital of Philadelphia, 3535 Market Street, Suite 860, Philadelphia, PA, 19104, USA.
Children's Hospital of Philadelphia · USAdelphi University · USIndiana University Bloomington · USMarquette University · USUniversity of Pennsylvania · US

Funding

The fusiform and amygalda in the pathobiology of autismR01MH073084 · NIMH · YALE UNIVERSITY · PI SCHULTZ, ROBERT THOMAS · 2005 to 2009
$1.6M
Developing a Community-Based ASD Research RegistryRC1MH088791 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI SCHULTZ, ROBERT THOMAS · 2009 to 2009
$500k
NIMH NIH HHS R01 MH073084NIMH NIH HHS RC1 MH088791
6 · The paper itself

Abstract

Recent studies suggest that longstanding findings of abnormal amygdala morphology in ASD may be related to symptoms of anxiety. To test this hypothesis, fifty-three children with ASD (mean age = 11.9) underwent structural MRI and were divided into subgroups to compare those with at least one anxiety disorder diagnosis (n = 29) to those without (n = 24) and to a typically developing control group (TDC; n = 37). Groups were matched on age and intellectual level. The ASD and anxiety group showed decreased right amygdala volume (controlled for total brain volume) relative to ASD without anxiety (p = .04) and TDCs (p = .068). Results suggest that youth with ASD and co-occurring anxiety have a distinct neurodevelopmental trajectory.

Indexed as

AdolescentAmygdalaAnxiety DisordersAutism Spectrum DisorderChildFemaleHumansMagnetic Resonance ImagingMaleOrgan SizeAmygdalaAnxiety disordersBrain morphometryComorbidity

Identifiers

PMID28689329
OpenAlexW2728094491

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.