Evidence map›Paper›PMID 28689254›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2017

Desensitization of the human 5-HT

Ulrich Gergs, Julia Fritsche, Stephanie Fabian, Josepha Christ, Joachim Neumann

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Mirtazapine is a functional antagonist at cardiac human HNaunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Cardiovascular effects of bufotenin on human 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2023
    Article
  6. Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease.International journal of molecular sciences · 2023
    Review
  7. Functional interaction of HNaunyn-Schmiedeberg's archives of pharmacology · 2021
    Article
  8. Amitriptyline functionally antagonizes cardiac HNaunyn-Schmiedeberg's archives of pharmacology · 2021
    Article
  9. Phosphodiesterases 2, 3 and 4 can decrease cardiac effects of HNaunyn-Schmiedeberg's archives of pharmacology · 2021
    Article
  10. Influence of Serotonin 5-HTBiomedicines · 2021
    Article
  11. Article
  12. Role of Cardiac AFrontiers in pharmacology · 2020
    Review
  13. Cardiovascular effects of cisapride and prucalopride on human 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ulrich GergsInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Str. 4, 06112, Halle, Germany. ulrich.gergs@medizin.uni-halle.de.ORCID http://orcid.org/0000-0001-6986-485X
Julia FritscheInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Str. 4, 06112, Halle, Germany.
Stephanie FabianInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Str. 4, 06112, Halle, Germany.
Josepha ChristInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Str. 4, 06112, Halle, Germany.
Joachim NeumannInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Str. 4, 06112, Halle, Germany.
Martin Luther University Halle-Wittenberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the human cardiovascular system, serotonin (5-HT) exerts positive inotropic and chronotropic effects mediated by 5-HT

Indexed as

AnimalsAtrial FunctionDose-Response Relationship, DrugHeart AtriaHumansIsolated Heart PreparationMiceMice, TransgenicMyocardial ContractionReceptors, Serotonin, 5-HT4SerotoninSerotonin 5-HT4 Receptor AgonistsReceptors, Serotonin, 5-HT4SerotoninSerotonin 5-HT4 Receptor Agonists5-HT4 receptorChronotropyDesensitizationInotropyTransgenic mouse

Identifiers

PMID28689254
OpenAlexW2734074692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.