Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2017
Multicenter, cross-sectional observational study of the impact of neuropathic pain on quality of life in cancer patients.
Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Adjusted Indirect and Mixed Comparisons of Drug Therapy for Neuropathic Cancer Pain.Pain research & management · 2026Pooled it
- Association of Pain With Mental and Physical Function in Patients With Chemotherapy-Induced Peripheral Neuropathy: A Secondary Analysis From Two Randomized Controlled Trials.Muscle & nerve · 2026Trial
- Significance of descriptive symptoms and signs and clinical parameters as predictors of neuropathic cancer pain.PloS one · 2021Trial
- Prevalence and factors associated with cancer-related neuropathic pain among cancer patients in Nigeria - a single-center cross-sectional study.Pain management · 2025Article
- Neuropathic Pain in Cancer: What Are the Current Guidelines?Current treatment options in oncology · 2024Review
- Cancer Pain Management: A Narrative Review of Current Concepts, Strategies, and Techniques.Current oncology (Toronto, Ont.) · 2023Review
- High-rate breakthrough cancer pain and tumour characteristics - literature review and case series.Drugs in context · 2023Review
- Fentanyl in cancer pain management: avoiding hasty judgments and discerning its potential benefits.Drugs in context · 2023Review
- Diagnosis, management and impact on patients' lives of cancer-related neuropathic pain (CRNP): A European survey.European journal of cancer care · 2022Article
- Survey of Opioid Risk Tool Among Cancer Patients Receiving Opioid Analgesics.Journal of Korean medical science · 2022Observational
- A structural equation modeling approach to understanding physical function of terminal cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- A Delphi Study on the Management of Neuropathic Cancer Pain in Spain: The DOLNEO Study.Journal of pain research · 2022Article
- Chemotherapy-Induced Peripheral Neuropathy: Epidemiology, Pathomechanisms and Treatment.Oncology and therapy · 2021Review
- Is Neuropathic Pain a Good Marker of Peripheral Neuropathy in Hospice Patients with Advanced Cancer? The Single Center Pilot Study.Diagnostics (Basel, Switzerland) · 2021Article
- Which factors can aid clinicians to identify a risk of pain during the following month in patients with bone metastases? A longitudinal analyses.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Long-term low-dose morphine for patients with moderate cancer pain is predominant factor effecting clinically meaningful pain reduction.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
- Neuropathic cancer pain: prevalence, pathophysiology, and management.The Korean journal of internal medicine · 2018Review
- A neuropathic pain component as a predictor of improvement in pain interference after radiotherapy for painful tumors: A secondary analysis of a prospective observational study.Clinical and translational radiation oncology · 2018Article
- Chronic neuropathic pain negatively associated with employment retention of cancer survivors: evidence from a national French survey.Journal of cancer survivorship : research and practice · 2018Article
- Pain Associated With Head and Neck Cancer Photoimmunotherapy.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
29 authors at 20 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNeuropathic cancer pain (NCP) is a common and potentially debilitating symptom in cancer patients. We investigated the prevalence of NCP, as well as its management and association with QOL.
methodsCancer patients with pain ≥1 on the visual analogue scale (VAS) were surveyed with the Douleur Neuropathique (DN4) questionnaire, the Brief Pain Inventory-Short Form (BPI-SF), and the EuroQOL five dimensions (EQ-5D) questionnaire. The associations between NCP and pain severity or NCP and QOL, while controlling for variables relevant to QOL, were then analyzed.
resultsA total of 2003 patients were enrolled in this survey; the prevalence of NCP was 36.0% (n = 722, 95% CI, 32.5-39.5). We found that NCP in cancer patients was closely correlated to a higher pain severity (BPI-SF; 4.96 ± 1.94 versus 4.24 ± 2.02, p < 0.001), and in patients with NCP, pain more severely interfered with daily living, as compared to those without NCP (BPI-SF; 4.86 ± 2.71 versus 4.41 ± 2.87, p < 0.001). Patients with NCP also had worse QOL than those without NCP, as measured by EQ-5D index score (0.47 ± 0.30 vs. 0.51 ± 0.30, p = 0.005), and this was confirmed using multivariate analysis (p < 0.001), even after controlling for other variables such as age, sex, disease stage, cancer duration, radiotherapy, chemotherapy, and comorbidities. Importantly, adjuvant analgesics were used in less than half of patients with NCP (n = 358, 46.4%).
conclusionsWe found that NCP in cancer patients was significantly associated with a worsened QOL, and current management is inadequate. Therefore, future research aimed at developing improved strategies for management of NCP is required.
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