Evidence map›Paper›PMID 28689109›Full record

ArticleEnvironment international2017

Organophosphate pesticides and PON1 L55M in Parkinson's disease progression.

Kimberly C Paul, Janet S Sinsheimer, Myles Cockburn, Jeff M Bronstein, Yvette Bordelon, Beate Ritz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
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  12. Parkinson's Disease Progression and Exposure to Contaminated Water at Camp Lejeune.Movement disorders : official journal of the Movement Disorder Society · 2024
    Article
  13. Review
  14. Article
  15. Paraoxonases at the Heart of Neurological Disorders.International journal of molecular sciences · 2023
    Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kimberly C PaulDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Janet S SinsheimerDepartment of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, California, USA; Departments of Human Genetics and Biomathematics, David Geffen School of Medicine, Los Angeles, California, USA.
Myles CockburnDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, USA.
Jeff M BronsteinDepartment of Neurology, David Geffen School of Medicine, Los Angeles, California, USA.
Yvette BordelonDepartment of Neurology, David Geffen School of Medicine, Los Angeles, California, USA.
Beate RitzDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA; Department of Neurology, David Geffen School of Medicine, Los Angeles, California, USA. Electronic address: britz@ucla.edu.
University of California, Los Angeles · USUCLA Health · USUniversity of Southern California · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joseph Leo Wiemels · 1996 to 2026
$46.4M
UCLA CENTER FOR THE STUDY OF PARKINSON'S DISEASEP50NS038367 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHESSELET, MARIE-FRANCOISE S · 1999 to 2011
$15.3M
STATISTICAL METHODS FOR GENE MAPPINGR01GM053275 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LANGE, KENNETH L · 1995 to 2019
$9.3M
Center for Gene-Environment Studies in Parkinson DiseaseU54ES012078 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHESSELET, MARIE-FRANCOISE S · 2002 to 2006
$7.1M
Project 4: Pesticides and Genes In PD: Studies In HumansP01ES016732 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KRANTZ, DAVID EVAN · 2008 to 2012
$6.7M
PARKINSON'S DISEASES SUSCEPTIBILITY GENES AND PESTICIDESR01ES010544 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2000 to 2015
$5.7M
Environmental Predictors of the Overlap of Neurodegenerative Disorders and Metabolic DysfunctionF32ES028087 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PAUL, KIMBERLY · 2017 to 2018
$121k
NIEHS NIH HHS F32 ES028087NIEHS NIH HHS P01 ES016732NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES010544NIEHS NIH HHS U54 ES012078NIGMS NIH HHS R01 GM053275NINDS NIH HHS P50 NS038367
6 · The paper itself

Abstract

backgroundParkinson's disease (PD) has motor and non-motor features that contribute to its phenotype and functional decline. Organophosphate (OP) pesticides and PON1 L55M, which influences OP metabolism, have been implicated in multiple mechanisms related to neuronal cell death and may influence PD symptom progression.

objectiveTo investigate whether ambient agricultural OP exposure and PON1 L55M influence the rate of motor, cognitive, and mood-related symptom progression in PD.

methodsWe followed a longitudinal cohort of 246 incident PD patients on average over 5years (7.5years after diagnosis), repeatedly measuring symptom progression with the Mini-Mental State Exam (MMSE), Unified Parkinson's Disease Rating Scale (UPDRS), and Geriatric Depressive Scale (GDS). OP exposures were generated with a geographic information system (GIS) based exposure assessment tool. We employed repeated-measures regression to assess associations between OP exposure and/or PON1 L55M genotype and progression.

resultsHigh OP exposures were associated with faster progression of motor (UPDRS β=0.24, 95% CI=-0.01, 0.49) and cognitive scores (MMSE β=-0.06, 95% CI=-0.11, -0.01). PON1 55MM was associated with faster progression of motor (UPDRS β=0.28, 95% CI=0.08, 0.48) and depressive symptoms (GDS β=0.07; 95% CI=0.01, 0.13). We also found the PON1 L55M variant to interact with OP exposures in influencing MMSE cognitive scores (β=-1.26, 95% CI=-2.43, -0.09).

conclusionOur study provides preliminary support for the involvement of OP pesticides and PON1 in PD-related motor, cognitive, or depressive symptom progression. Future studies are needed to replicate findings and examine whether elderly populations generally are similarly impacted by pesticides or PON1 55M genotypes.

Indexed as

Parkinson DiseaseAgedAged, 80 and overAgricultureAryldialkylphosphataseCaliforniaCognitionCohort StudiesDepressionDisease ProgressionEnvironmental ExposureFemaleGenotypeHumansMaleMiddle AgedAryldialkylphosphataseOrganophosphatesPesticidesPON1 protein, humanCognitive declineOrganophosphatesParkinson's diseasePON1Progression

Identifiers

PMID28689109
PMCPMC5600289
OpenAlexW2729668267

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.