ArticleNeuroscience letters2017
Projection targets of medial frontal D1DR-expressing neurons.
Article in Neuroscience letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Dopaminergic projections to the prefrontal cortex are critical for rapid threat avoidance learning.Current biology : CB · 2025Article
- Immediate glucose signaling transmitted via the vagus nerve in gut-brain neural communication.iScience · 2025Article
- Generation and validation of a D1 dopamine receptor Flpo knock-in mouse.Journal of neuroscience methods · 2025Article
- Adolescent alcohol exposure reduces dopamine 1 receptor modulation of prelimbic neurons projecting to the nucleus accumbens and basolateral amygdala.Addiction neuroscience · 2022Article
- Distinct Role of Dopamine in the PFC and NAc During Exposure to Cocaine-Associated Cues.The international journal of neuropsychopharmacology · 2021Article
- Cortical Foxp2 Supports Behavioral Flexibility and Developmental Dopamine D1 Receptor Expression.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Temporal Learning Among Prefrontal and Striatal Ensembles.Cerebral cortex communications · 2020Article
- Corticostriatal stimulation compensates for medial frontal inactivation during interval timing.Scientific reports · 2019Article
- Dopaminergic D1 receptor effects on commissural inputs targeting layer V pyramidal subtypes of the mouse medial prefrontal cortex.Physiological reports · 2019Article
- Cell-Type-Specific D1 Dopamine Receptor Modulation of Projection Neurons and Interneurons in the Prefrontal Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Dopamine tunes prefrontal outputs to orchestrate aversive processing.Brain research · 2019Review
- Prefrontal D1 Dopamine-Receptor Neurons and Delta Resonance in Interval Timing.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
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Authors and funding
3 authors.
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Abstract
Prefrontal neurons expressing D1-type dopamine receptors (D1DRs) have been implicated in a variety of cognitive processes including working memory and timing. Although D1DRs are most strongly expressed on layer V/VI projection neurons, it is unknown which brain areas are specifically targeted by these projections. Here we selectively marked D1DR neurons using cre-loxP techniques with AAV carrying mCherry fluorescent protein, and traced projection targets of D1DR+ neurons in the mouse medial frontal cortex (MFC). We found relatively strong MFC D1DR+ projections to cortical areas as well as projections to basal ganglia and thalamic nuclei. We found relatively weaker MFC D1DR+ projections to the brainstem, hypothalamus, and other subcortical nuclei. These data intimate that MFC D1DR+ projections are well-positioned to powerfully influence cortical processing and have subcortical specificity. Thus MFC D1DR+ projection neurons may play a key role in tuning cortical networks during goal-directed behavior.
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