Evidence map›Paper›PMID 28688895›Full record

ArticleDevelopmental biology2017

Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model.

Maria A Hoelzl, Karin Heby-Henricson, Marco Gerling, José M Dias, Raoul V Kuiper, Cornelius Trünkle, Åsa Bergström, Johan Ericson, Rune Toftgård, Stephan Teglund

Open access · greenAbstract read
In one paragraph

Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Ventral body wall closure: Mechanistic insights from mouse models and translation to human pathology.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Review
  3. Article
  4. Hedgehog Signaling in Colorectal Cancer: All in the Stroma?International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Maria A HoelzlDepartment of Biosciences and Nutrition, Karolinska Institutet, SE-141 83 Huddinge, Sweden. Electronic address: maria.holzl@ki.se.
Karin Heby-HenricsonDepartment of Biosciences and Nutrition, Karolinska Institutet, SE-141 83 Huddinge, Sweden.
Marco GerlingDepartment of Biosciences and Nutrition, Karolinska Institutet, SE-141 83 Huddinge, Sweden.
José M DiasDepartment of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Raoul V KuiperDepartment of Laboratory Medicine, Karolinska Institutet, SE-141 86 Huddinge, Sweden.
Cornelius TrünkleDepartment of Biosciences and Nutrition, Karolinska Institutet, SE-141 83 Huddinge, Sweden.
Åsa BergströmDepartment of Biosciences and Nutrition, Karolinska Institutet, SE-141 83 Huddinge, Sweden.
Johan EricsonDepartment of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Rune ToftgårdDepartment of Biosciences and Nutrition, Karolinska Institutet, SE-141 83 Huddinge, Sweden.
Stephan TeglundDepartment of Biosciences and Nutrition, Karolinska Institutet, SE-141 83 Huddinge, Sweden. Electronic address: stephan.teglund@ki.se.
Karolinska Institutet · SE

Funding

Sonic hedgehog in skin /appendage developmentP01AR047898 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI ROOP, DENNIS · 2001 to 2005
$6.8M
NIAMS NIH HHS P01 AR047898
6 · The paper itself

Abstract

Suppressor of Fused (SUFU) is an essential negative regulator of the Hedgehog (HH) pathway and involved in GLI transcription factor regulation. Due to early embryonic lethality of Sufu

Indexed as

OrganogenesisAllelesAnimalsBody PatterningEmbryo, MammalianExonsFemaleGene Expression Regulation, DevelopmentalHedgehog ProteinsHomozygoteMaleMice, Inbred BALB CMice, Inbred C57BLMice, NudeModels, AnimalNeural TubeHedgehog ProteinsRepressor ProteinsRNA, MessengerRNA Splice SitesSufu protein, mouseEmbryogenesisGLIHedgehog pathwayHypomorphSkeletogenesisSuppressor of Fused

Identifiers

PMID28688895
PMCPMC5569906
OpenAlexW2728515492

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.