ReviewTrends in neurosciences2017
The Lateral Habenula and Adaptive Behaviors.
Review in Trends in neurosciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Significant heterogeneity in structural asymmetry of the habenula in the human brain: A systematic review and meta-analysis.Human brain mapping · 2023Pooled it
- Response Flexibility: The Role of the Lateral Habenula.Frontiers in behavioral neuroscience · 2022Pooled it
- Deep Brain Stimulation of the Habenula: Systematic Review of the Literature and Clinical Trial Registries.Frontiers in psychiatry · 2021Pooled it
- Habenula Alterations in Resting-State Functional Connectivity Among Autistic Individuals.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Ancestral organisation and asymmetric circuit architecture of the habenula revealed in a basal ray-finned fish.Brain structure & function · 2026Article
- Serotonin deficiency caused by inactivation of Tph2 in mice leads to widespread sex-dependent changes in cerebral oxidative metabolic activity.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Whole-Brain Mapping of Neuronal Activity Associated with Vocal Socialization Behaviors in Adult Mice.eNeuro · 2026Article
- The lateral habenula as a master regulator of innate and learned social behaviors.Psychopharmacology · 2026Review
- Lateral habenula and periaqueductal gray neurons signal reward prediction error and continuity of reward expectancy to drive reward-seeking behavior.Cell reports · 2026Article
- Deep Brain Stimulation of Lateral Habenula Ameliorates Depression-like Symptoms in Rats: Involvement of Mesolimbic Circuit.Neurochemical research · 2026Article
- Ventral pallidum efferent pathways via mediodorsal thalamus and lateral habenula mediate default mode network regulation.iScience · 2025Article
- Nash equilibrium of attack and defense behaviors between predators and prey.PLoS computational biology · 2025Article
- Habenula contributions to negative self-cognitions.Nature communications · 2025Article
- Brain circadian clocks timing the 24h rhythms of behavior.Npj biological timing and sleep · 2025Review
- Periaqueductal gray passes over disappointment and signals continuity of remaining reward expectancy.Research square · 2025Article
- Periaqueductal gray passes over disappointment and signals continuity of remaining reward expectancy.bioRxiv : the preprint server for biology · 2024Article
- Role of Neural Circuits in Cognitive Impairment.Neurochemical research · 2024Review
- The role of the mediodorsal thalamus in chemosensory preference and consummatory behavior in rats.Chemical senses · 2024Article
- The dopaminergic system mediates the lateral habenula-induced autonomic cardiovascular responses.Frontiers in physiology · 2024Article
- Sexual Dimorphism of Inputs to the Lateral Habenula in Mice.Neuroscience bulletin · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The evolutionarily conserved lateral habenula (LHb) enables dynamic responses to continually changing contexts and environmental conditions. A model is proposed to account for greater mnemonic and contextual control over LHb-mediated response flexibility as vertebrate brains became more complex. The medial prefrontal cortex (mPFC) provides instructions for context-specific responses to LHb, which assesses the extent to which this response information matches the motivation or internal state of the individual. LHb output either maintains a prior response (match) or leads to alternative responses (mismatch). It may also maintain current spatial and temporal processing in hippocampus (match), or alter such activity to reflect updated trajectory and sequenced information (mismatch). A response flexibility function of the LHb is consistent with poor behavioral control following its disruption (e.g., in depression).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.