ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2017
White Matter Lesions are Associated with Specific Depressive Symptom Trajectories among Incident Depression and Dementia Populations: Three-City Dijon MRI Study.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies.Frontiers in neurology · 2019Pooled it
- Associations of Midlife Vascular Risk Factors With Late-Life Depressive Symptoms: Findings From the ARIC Study.Journal of the American Heart Association · 2026Article
- Longitudinal Changes in White Matter Hypointensities in Recurrent Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Iron deficiency and depression: evidence of critical risk periods.Frontiers in psychiatry · 2026Article
- Review
- Research status and global trends of late-life depression from 2004 to 2023: bibliometric analysis.Frontiers in aging neuroscience · 2024Article
- The clinical and neuropsychological profiles of Alzheimer's disease with white matter hyperintensity in North China.Frontiers in neurology · 2024Article
- Under pressure: A systematic review of the association between blood pressure variability with depression and anxiety.Cerebral circulation - cognition and behavior · 2024Article
- Associations between mental health, blood pressure and the development of hypertension.Nature communications · 2023Article
- Development and validation of a predictive model for white matter lesions in young- and middle-aged people.Frontiers in neurology · 2023Article
- Orbitofrontal and Cingulate Thickness Asymmetry Associated with Depressive Symptom Dimensions.Cognitive, affective & behavioral neuroscience · 2021Article
- Brain-based mechanisms of late-life depression: Implications for novel interventions.Seminars in cell & developmental biology · 2021Review
- Diastolic Blood Pressure Is Associated With Regional White Matter Lesion Load: The Northern Manhattan Study.Stroke · 2020Article
- Impact of white matter hyperintensity location on depressive symptoms in memory-clinic patients: a lesion–symptom mapping studyJournal of psychiatry & neuroscience : JPN · 2019Article
- Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based Studies.Journal of stroke · 2019Review
- Stopping Cognitive Decline in Patients With Late-Life Depression: A New Front in the Fight Against Dementia.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018Article
- Apathy and depressive symptoms in older people and incident myocardial infarction, stroke, and mortality: a systematic review and meta-analysis of individual participant data.Clinical epidemiology · 2018Review
- Clinical Findings Documenting Cellular and Molecular Abnormalities of Glia in Depressive Disorders.Frontiers in molecular neuroscience · 2018Review
- The Multi-Faceted Relationship between White Matter Lesions and Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEvidence is mixed as to whether periventricular or deep white matter hyperintensities (WMHs) increase the risk for depressive symptoms, partly because of heterogeneity in depression measurement, short follow-up, and confounding by prodromal dementia. The study objective was to evaluate WMH volume in relation to discrete depressive symptoms over 10 years, stratifying by incident depression and dementia.
methodsIn this prospective longitudinal cohort study of a representative population sample from Dijon, France, 1,440 participants aged 65-80 years (median age: 72 years; 59.5% women) without depression, dementia, or stroke at baseline were studied. Baseline T2-weighted images were obtained in a 1.5-T scanner to quantify WMHs (log cm
resultsPeriventricular WMH volume was uniquely associated with low positive affect among incident depression cases (β = 0.15; 95% confidence interval [CI]: 0.02-0.29; p = 0.026). Deep WMH volume was uniquely associated with depressed affect among incident dementia cases (β = 0.36; 95% CI: 0.05-0.68; p = 0.025). WMH volume (periventricular, deep, and total) was associated with interpersonal problems among persons who developed dementia with depression.
conclusionThe findings highlight that regional WMH volumes and specific depressive symptoms have clinical and prognostic relevance to help differentiate between persons at risk for depression and dementia.
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