ArticleSchizophrenia research2018
Stronger default mode network connectivity is associated with poorer clinical insight in youth at ultra high-risk for psychotic disorders.
Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Mental time travel and insight in schizophrenia.Psychological medicine · 2025Review
- Reduced glymphatic clearance in early psychosis.Molecular psychiatry · 2025Article
- Persons at risk for psychosis overestimate social functioning compared to persons with major depressive disorder and community controls.Journal of psychiatric research · 2025Article
- Comparing reliability-based measures of functional connectivity between movie and rest: An ROI-based approach.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The unique role of anosognosia in the clinical progression of Alzheimer's disease: a disorder-network perspective.Communications biology · 2024Review
- Functional magnetic resonance imaging in schizophrenia: current evidence, methodological advances, limitations and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Clinical anatomy of the precuneus and pathogenesis of the schizophrenia.Anatomical science international · 2023Review
- Interactions between the cortical midline structures and sensorimotor network track maladaptive self-beliefs in clinical high risk for psychosis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Weaker Cerebellocortical Connectivity Within Sensorimotor and Executive Networks in Schizophrenia Compared to Healthy Controls: Relationships with Processing Speed.Brain connectivity · 2020Article
- Defining Individual-Specific Functional Neuroanatomy for Precision Psychiatry.Biological psychiatry · 2020Review
- Selective Review of Neuroimaging Findings in Youth at Clinical High Risk for Psychosis: On the Path to Biomarkers for Conversion.Frontiers in psychiatry · 2020Review
- Psychosis risk is associated with decreased resting-state functional connectivity between the striatum and the default mode network.Cognitive, affective & behavioral neuroscience · 2019Article
- Distinct and opposite profiles of connectivity during self-reference task and rest in youth at clinical high risk for psychosis.Human brain mapping · 2019Article
- Predictors of Outcomes in Adolescents With Clinical High Risk for Psychosis, Other Psychiatric Symptoms, and Psychosis: A Longitudinal Protocol Study.Frontiers in psychiatry · 2019Article
- Connecting Mind, Brain, and Seizures by Default Mode.Epilepsy currentsArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Impaired clinical insight (CI) is a common symptom of psychotic disorders and a promising treatment target. However, to date, our understanding of how variability in CI is tied to underlying brain dysfunction in the clinical high-risk period is limited. Developing a stronger conception of this link will be a vital first step for efforts to determine if CI can serve as a useful prognostic indicator. The current study investigated whether variability in CI is related to major brain networks in adolescents and young adults at ultra high-risk (UHR) of developing psychosis. Thirty-five UHR youth were administered structured clinical interviews as well as an assessment for CI and underwent resting-state magnetic resonance imaging scans. Functional connectivity was calculated in the default mode network (DMN) and fronto-parietal network (FPN), two major networks that are dysfunctional in psychosis and are hypothesized to affect insight. Greater DMN connectivity between the posterior cingulate/precuneus and ventromedial prefrontal cortex (DMN) was related to poorer CI (R
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