Evidence map›Paper›PMID 28688575›Full record

ReviewTrends in microbiology2017

Natural-Product Antibiotics: Cues for Modulating Bacterial Biofilm Formation.

Loni Townsley, Elizabeth A Shank

Open access · greenAbstract readReview
In one paragraph

Review in Trends in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Biofilm-associated genes inFrontiers in microbiology · 2026
    Review
  3. Article
  4. The EpiphyteBiomolecules · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Novel Antibiofilm Inhibitor Ginkgetin as an Antibacterial Synergist againstInternational journal of molecular sciences · 2022
    Article
  13. Review
  14. Article
  15. Effects of daphnetin on biofilm formation and motility ofFrontiers in cellular and infection microbiology · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Loni TownsleyDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Elizabeth A ShankDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Curriculum of Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: eshank@unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Using Co-culture and Bioinformatics to Discover New Antibiotic BioactivitiesR01GM112981 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHANK, ELIZABETH ANNE · 2016 to 2020
$1.4M
NIGMS NIH HHS R01 GM112981
6 · The paper itself

Abstract

Cell-cell communication enables bacteria to coordinate their behavior through the production, recognition, and response to chemical signals produced by their microbial neighbors. An important example of coordinated behavior in bacteria is biofilm formation, where individual cells organize into highly complex, matrix-encased communities that differentiate into distinct cell types and divide labor among individual cells. Bacteria rely on environmental cues to influence biofilm development, including chemical cues produced by other microbes. A multitude of recent studies have demonstrated that natural-product antibiotics at subinhibitory concentrations can impact biofilm formation in neighboring microbes, supporting the hypothesis that these compounds may have evolved as signaling molecules that mediate cell-cell interactions. In this review we discuss the role of antibiotics in modulating biofilm formation and interspecies communication in bacteria.

Indexed as

Anti-Bacterial AgentsBacteriaBiofilmsBiological ProductsQuorum SensingSignal TransductionAnti-Bacterial AgentsBiological Productsbacterial interactionsbiofilm formationcell–cell communicationnatural productsspecialized metabolites

Identifiers

PMID28688575
PMCPMC5701842
OpenAlexW2726622473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.