ArticleIranian biomedical journal2017
Molecular Identification and Antifungal Susceptibility Pattern of Non-albicans Candida Species Isolated from Vulvovaginal Candidiasis
Article in Iranian biomedical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 25 citations in OpenAlex.
- Molecular epidemiology ofVirulence · 2025Article
- Exploring the female genital tract mycobiome in young South African women using metaproteomics.Microbiome · 2025Article
- A multi-kingdom collection of 33,804 reference genomes for the human vaginal microbiome.Nature microbiology · 2024Article
- Characterization ofCurrent medical mycology · 2021Article
- The influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains.Scientific reports · 2021Article
- Vaginal microbiota evaluation and prevalence of key pathogens in ecuadorian women: an epidemiologic analysis.Scientific reports · 2020Article
- In vitro antifungal resistance profile of Candida strains isolated from Saudi women suffering from vulvovaginitis.European journal of medical research · 2020Article
- Antifungal and Antivirulence Activity of VaginalPathogens (Basel, Switzerland) · 2019Article
- Update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA 9: suitability of taxonomic units notified to EFSA until September 2018.EFSA journal. European Food Safety Authority · 2019Article
- Species distribution and susceptibility profiles of Candida species isolated from vulvovaginal candidiasis, emergence of C. lusitaniae.Current medical mycology · 2019Article
- Comparative Analysis of the Capacity of theInfection and immunity · 2018Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
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Abstract
Background: Vulvovaginal candidiasis (VVC) is an important health problem caused by Candida spp. The aim of this study was molecular identification, phylogenetic analysis, and evaluation of antifungal susceptibility of non-albicans Candida isolates from VVC. Methods: Vaginal secretion samples were collected from 550 vaginitis patients at Sayyad Shirazi Medical and Educational Center of Gorgan (Golestan Province, Iran) from May to October 2015. Samples were analyzed using conventional mycological and molecular approaches. Clinical isolates were analyzed with specific PCR using CGL primers, and the internal transcribed spacer region and the D1-D2 domain of the large-subunit rRNA gene were amplified and sequenced. Susceptibility to amphotericin B, fluconazole, itraconazole, and clotrimazole was determined by the guidelines of the Clinical and Laboratory Standard Institute. Results: In total, 35 non-albicans Candida isolates were identified from VVC patients. The isolates included 27 strains of Candida glabrata (77.1%), 5 Candida krusei (Pichia kudriavzevii; 14.3%), 2 Candida kefyr (Kluyveromyces marxianus; 5.7%), and 1 Candida lusitaniae (Clavispora lusitaniae; 2.9%). The fungicides itraconazole and amphotericin B were effective against all species. One isolate of C. glabrata showed resistance to fluconazole and clotrimazole, and 26 isolates of C. glabrata indicated dose-dependent susceptibility to fluconazole. C. lusitaniae was susceptible in a dose-dependent manner to fluconazole and resistant to clotrimazole. Conclusion: Non-albicans Candida spp. are common agents of vulvovaginitis, and C. glabrata is the most common species in the tested patients.
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