ArticleJournal of affective disorders2017
White matter correlates of impaired attention control in major depressive disorder and healthy volunteers.
Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Cerebral diffusion kurtosis imaging to assess the pathophysiology of postpartum depression.Scientific reports · 2020Trial
- White matter and impulsivity are prospectively associated with non‑suicidal self‑injury in youth: evidence for sex differences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Association Between White Matter Tract Integrity and Frontal-Executive Function in Non-Geriatric Adult Patients With Major Depressive Disorder.Psychiatry investigation · 2024Article
- Research on the Mechanism of Cognitive Decline in Patients With Acoustic Neuroma.Frontiers in neuroscience · 2022Article
- Diffusion tensor imaging brain structural clustering patterns in major depressive disorder.Human brain mapping · 2021Article
- Brain-based mechanisms of late-life depression: Implications for novel interventions.Seminars in cell & developmental biology · 2021Review
- White matter abnormalities and cognitive function in euthymic patients with bipolar disorder and major depressive disorder.Brain and behavior · 2020Article
- Disrupted Structural Brain Network Organization Behind Depressive Symptoms in Major Depressive Disorder.Frontiers in psychiatry · 2020Article
- Behavioral inhibition corresponds to white matter fiber bundle integrity in older adults.Brain imaging and behavior · 2019Article
- Gray matter volumetric study of major depression and suicidal behavior.Psychiatry research. Neuroimaging · 2019Article
- White matter abnormalities predict residual negative self-referential thinking following treatment of late-life depression with escitalopram: A preliminary study.Journal of affective disorders · 2019Article
- Improvement Of Frontal Lobe Dysfunction And White Matter Integrity By rTMS In Treatment-Resistant Depression.Neuropsychiatric disease and treatment · 2019Article
- Development and evaluation of a multimodal marker of major depressive disorder.Human brain mapping · 2018Article
- Article
- A computational network control theory analysis of depression symptoms.Personality neuroscience · 2018Article
- Abnormal brain white matter in patients with right trigeminal neuralgia: a diffusion tensor imaging study.The journal of headache and pain · 2018Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundMajor depressive disorder (MDD) is associated with impaired attention control and alterations in frontal-subcortical connectivity. We hypothesized that attention control as assessed by Stroop task interference depends on white matter integrity in fronto-cingulate regions and assessed this relationship using diffusion tensor imaging (DTI) in MDD and healthy volunteers (HV).
methodsDTI images and Stroop task were acquired in 29 unmedicated MDD patients and 16 HVs, aged 18-65 years. The relationship between Stroop interference and fractional anisotropy (FA) was examined using region-of-interest (ROI) and tract-based spatial statistics (TBSS) analyses.
resultsROI analysis revealed that Stroop interference correlated positively with FA in left caudal anterior cingulate cortex (cACC) in HVs (r = 0.62, p = 0.01), but not in MDD (r = -0.05, p= 0.79) even after controlling for depression severity. The left cACC was among 4 ROIs in fronto-cingulate network where FA was lower in MDD relative to HVs (F LIMITATIONS: The modest sample size limits the generalizability of the findings.
conclusionsStructural connectivity of white matter network of cACC correlated with magnitude of Stroop interference in HVs, but not MDD. The cACC-frontal network, sub-serving attention control, may be disrupted in MDD. Less cognitive control may include enhanced effects of salience in HVs, or less effective response inhibition in MDD. Further studies of salience and inhibition components of executive function may better elucidate the relationship between brain white matter changes and executive dysfunction in MDD.
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