Evidence map›Paper›PMID 28688028›Full record

ArticleLung2017

Novel Assessment of Interstitial Lung Disease Using the "Computer-Aided Lung Informatics for Pathology Evaluation and Rating" (CALIPER) Software System in Idiopathic Inflammatory Myopathies.

Patompong Ungprasert, Katelynn M Wilton, Floranne C Ernste, Sanjay Kalra, Cynthia S Crowson, Srinivasan Rajagopalan, Brian J Bartholmai

Abstract read
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In one paragraph

Article in Lung, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. A systematic review of the role of quantitative CT in the prognostication and disease monitoring of interstitial lung disease.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
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  5. Observational
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  9. Towards Treatable Traits for Pulmonary Fibrosis.Journal of personalized medicine · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Patompong UngprasertDivision of Rheumatology, Department of Medicine, Mayo Clinic in Rochester, Mayo East15, 200 First Street SW, Rochester, MN, 55905, USA.
Katelynn M WiltonMayo Medical Scientist Training Program, Mayo Clinic in Rochester, Rochester, MN, USA.
Floranne C ErnsteDivision of Rheumatology, Department of Medicine, Mayo Clinic in Rochester, Mayo East15, 200 First Street SW, Rochester, MN, 55905, USA. ernste.floranne@mayo.edu.
Sanjay KalraDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic in Rochester, Rochester, MN, USA.
Cynthia S CrowsonDivision of Rheumatology, Department of Medicine, Mayo Clinic in Rochester, Mayo East15, 200 First Street SW, Rochester, MN, 55905, USA.
Srinivasan RajagopalanDepartment of Physiology and Biomedical Engineering, Biomedical Imaging Resource, Mayo Clinic in Rochester, Rochester, MN, USA.
Brian J BartholmaiDepartment of Radiology, Mayo Clinic in Rochester, Rochester, MN, USA.
Mayo Clinic · USMayo Clinic in Florida · USSiriraj Hospital · THWinnMed · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Medical Scientist Traning Program at Mayo ClinicT32GM065841 · NIGMS · MAYO CLINIC ROCHESTER · PI KAUFMANN, SCOTT H, SCHIMMENTI, LISA A · 2003 to 2022
$5.8M
National Center for Advancing Translational Sciences UL1 TR000135National Institute of General Medical Sciences T32 GM 65841
6 · The paper itself

Abstract

purposeTo evaluate the correlation between measurements from quantitative thoracic high-resolution CT (HRCT) analysis with "Computer-Aided Lung Informatics for Pathology Evaluation and Rating" (CALIPER) software and measurements from pulmonary function tests (PFTs) in patients with idiopathic inflammatory myopathies (IIM)-associated interstitial lung disease (ILD).

methodsA cohort of patients with IIM-associated ILD seen at Mayo Clinic was identified from medical record review. Retrospective analysis of HRCT data and PFTs at baseline and 1 year was performed. The abnormalities in HRCT were quantified using CALIPER software.

resultsA total of 110 patients were identified. At baseline, total interstitial abnormalities as measured by CALIPER, both by absolute volume and by percentage of total lung volume, had a significant negative correlation with diffusing capacity for carbon monoxide (DLCO), total lung capacity (TLC), and oxygen saturation. Analysis by subtype of interstitial abnormality revealed significant negative correlations between ground glass opacities (GGO) and reticular density (RD) with DLCO and TLC. At one year, changes of total interstitial abnormalities compared with baseline had a significant negative correlation with changes of TLC and oxygen saturation. A negative correlation between changes of total interstitial abnormalities and DLCO was also observed, but it was not statistically significant. Analysis by subtype of interstitial abnormality revealed negative correlations between changes of GGO and RD and changes of DLCO, TLC, and oxygen saturation, but most of the correlations did not achieve statistical significance.

conclusionCALIPER measurements correlate well with functional measurements in patients with IIM-associated ILD.

Indexed as

SoftwareAdultAgedCarbon MonoxideCohort StudiesFemaleHumansImage Processing, Computer-AssistedImaging, Three-DimensionalLungLung Diseases, InterstitialMaleMiddle AgedMultidetector Computed TomographyMyositisPulmonary Diffusing CapacityCarbon MonoxideHigh-resolution computed tomographyImaging biomarkersInflammatory myopathiesInterstitial lung diseaseQuantitative imagingTexture analysis software

Identifiers

PMID28688028
OpenAlexW2727258881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.