Evidence map›Paper›PMID 28687932›Full record

ArticleJournal of molecular histology2017

Spatial and temporal expression of Sox9 during murine incisor development.

Zhi-Cheng Yang, Dan Li, Shuang Feng, Xiao-Dong Sui, Zhi Chen, Li Zhang

Abstract read
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Article in Journal of molecular histology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zhi-Cheng YangDepartment of Stomatology, Yantai Affiliated Hospital of Binzhou Medical University, No. 717 Jinbu Street, Yantai, 264100, Shandong, China.
Dan LiBinzhou Medical University, No. 346 Guanhai Street, Yantai, 264003, Shandong, China.
Shuang FengBinzhou Medical University, No. 346 Guanhai Street, Yantai, 264003, Shandong, China.
Xiao-Dong SuiBinzhou Medical University, No. 346 Guanhai Street, Yantai, 264003, Shandong, China.
Zhi ChenState Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine of Ministry of Education (KLOBM), School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, China. zhichen@whu.edu.cn.
Li ZhangDepartment of Stomatology, Yantai Affiliated Hospital of Binzhou Medical University, No. 717 Jinbu Street, Yantai, 264100, Shandong, China. anniezhangli001@163.com.
Binzhou Medical University · CNBinzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mouse incisors are capable of continuously growing due to the renewal of dental epithelium stem cells and mesenchymal stem cells residing at the proximal ends. The transcription factor Sox9 plays important roles in maintaining the stem cells of hair follicles, retinal progenitor cells and neural crest stem cells. Whether Sox9 is involved during mouse incisor development is not reported yet. In this study, we examined the expression pattern of Sox9 during mouse incisor development by in situ hybridization and immunohistochemistry. Sox9 mRNA and protein showed similar expression pattern from embryonic day (E) 13.5 to postnatal (PN) day 10. At E13.5 and E14.5, Sox9 was strongly expressed in the dental epithelium. At E16.5, Sox9 started to be detected in the mesenchymal cells within the dental pulp, especially the dental pulp cells that adjacent to the labial cervical loop. Similarly with E14.5, Sox9 was strongly detected in the labial cervical loop, including the basal epithelium, the stellate reticulum and the outer enamel epithelium from E16.5 to PN10. The mesenchyme adjacent to the labial cervical loop also showed strong signal of Sox9. The spatiotemporal expression of Sox9 suggested its possible involvement during mouse incisor development.

Indexed as

Gene Expression Regulation, DevelopmentalSpatio-Temporal AnalysisAnimalsDental PulpEpitheliumImmunohistochemistryIncisorIn Situ HybridizationMesenchymal Stem CellsMiceSOX9 Transcription FactorTime FactorsSox9 protein, mouseSOX9 Transcription FactorEpithelium stem cellIn situ hybridization and immunohistochemistryMouse incisorSox9

Identifiers

PMID28687932
OpenAlexW2729422639

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.