ArticleJournal of neuro-oncology2017
Definitive chemoradiation at high volume facilities is associated with improved survival in glioblastoma.
Article in Journal of neuro-oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Systematic Review and Meta-analysis of the Association Between Radiation Therapy Treatment Volume and Patient Outcomes.International journal of radiation oncology, biology, physics · 2023Pooled it
- Association of hospital volume with survival but not with postoperative mortality in glioblastoma patients in Belgium.Journal of neuro-oncology · 2024Article
- Does waiting for surgery matter? How time from diagnostic MRI to resection affects outcomes in newly diagnosed glioblastoma.Journal of neurosurgery · 2024Article
- Epidemiological characteristics and genetic alterations in adult diffuse glioma in East Asian populations.Cancer biology & medicine · 2022Review
- Cyclin G2 reverses immunosuppressive tumor microenvironment and potentiates PD-1 blockade in glioma.Journal of experimental & clinical cancer research : CR · 2021Article
- Improved outcomes associated with maximal extent of resection for butterfly glioblastoma: insights from institutional and national data.Acta neurochirurgica · 2021Article
- Disparities in glioblastoma survival by case volume: a nationwide observational study.Journal of neuro-oncology · 2020Observational
- Long noncoding RNA lysophospholipase-like 1-2 as ceRNA modulates glioma metastasis by regulating miR-217/YWHAG.American journal of translational research · 2020Article
- Glioblastoma-Derived IL6 Induces Immunosuppressive Peripheral Myeloid Cell PD-L1 and Promotes Tumor Growth.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Article
- The impact of traveling distance and hospital volume on post-surgical outcomes for patients with glioblastoma.Journal of neuro-oncology · 2019Article
- Clinical benefit of treatment for metastatic renal cell cancer at high volume facilities.Annals of translational medicine · 2018Article
- National Cancer Database report of nonmetastatic esophageal small cell carcinoma.Cancer medicine · 2018Article
- Chemoradiotherapy versus chemotherapy alone for unresected intrahepatic cholangiocarcinoma: practice patterns and outcomes from the national cancer data base.Journal of gastrointestinal oncology · 2018Article
- Utilization of intensity modulated radiation therapy for anal cancer in the United States.Journal of gastrointestinal oncology · 2018Article
- Practice patterns and outcomes of chemoradiotherapy versus radiotherapy alone for older patients with nasopharyngeal cancer.Cancer medicine · 2018Article
- Utilization of neoadjuvant intensity-modulated radiation therapy and proton beam therapy for esophageal cancer in the United States.Journal of gastrointestinal oncology · 2018Article
- Radiation dose in neoadjuvant chemoradiation therapy for esophageal cancer: patterns of care and outcomes from the National Cancer Data Base.Journal of gastrointestinal oncology · 2018Article
- Addition of chemotherapy to hypofractionated radiotherapy for glioblastoma: practice patterns, outcomes, and predictors of survival.Journal of neuro-oncology · 2018Article
- Association of Treatment at High-Volume Facilities With Survival in Patients Receiving Chemoradiotherapy for Nasopharyngeal Cancer.JAMA otolaryngology-- head & neck surgery · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The standard of care for glioblastoma (GBM) is maximal safe resection followed by concurrent chemoradiation (CRT). For several neoplasms, receipt of radiation treatment at high-volume facilities has been associated with improved overall survival (OS). The purpose of the present investigation was to determine if there was an association between receipt of CRT for GBM at facilities with a higher case volume and improved OS. The National Cancer Data Base was queried for patients with GBM diagnosed between 2006 and 2012 that received full-course CRT. Statistics included Kaplan-Meier analysis to compare OS between patients treated facilities with the highest quartile volume (HVF) to those treated at lower case volume facilities, multivariate logistic regression to determine factors associated with treatment at a HVF, and Cox proportional hazards modeling to determine variables associated with OS. A total of 4892 patients met the specified criteria. Fourteen facilities (9.9%) treated the highest quartile volume of patients, while 69 (48.6%) treated the lowest quartile volume (LVF) of patients. Treatment at the HVF was associated with improved median OS (16.5 vs. 14.1 months, p < 0.001). Treatment at a LVF also independently predicted for worse OS on multivariate analysis, along with age >70 years, and a resection limited to a biopsy. This is the first study to demonstrate that treatment of GBM with CRT at a HVF is associated with improved survival. Major goals of future oncologic care should be to achieve greater standardization of quality of treatment across facilities with different case volumes.
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