Evidence map›Paper›PMID 28687822›Full record

ArticleJournal of biomedical optics2017

Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography.

Hsiang-Chieh Lee, Osman O Ahsen, Jonathan J Liu, Tsung-Han Tsai, Qin Huang, Hiroshi Mashimo, James G Fujimoto

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hsiang-Chieh LeeMassachusetts Institute of Technology, Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Cambridge, Massachusetts, United States.
Osman O AhsenMassachusetts Institute of Technology, Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Cambridge, Massachusetts, United States.
Jonathan J LiuMassachusetts Institute of Technology, Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Cambridge, Massachusetts, United States.
Tsung-Han TsaiMassachusetts Institute of Technology, Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Cambridge, Massachusetts, United States.
Qin HuangVeterans Affairs Boston Healthcare System, Boston, Massachusetts, United StatescHarvard Medical School, Boston, Massachusetts, United States.
Hiroshi MashimoVeterans Affairs Boston Healthcare System, Boston, Massachusetts, United StatescHarvard Medical School, Boston, Massachusetts, United States.
James G FujimotoMassachusetts Institute of Technology, Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Cambridge, Massachusetts, United States.

Funding

Novel Optical Diagnostics with Optical Coherence TomographyR01EY011289 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JAMES G FUJIMOTO · 1995 to 2026
$9.5M
OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHYR01CA075289 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FUJIMOTO, JAMES G, MASHIMO, HIROSHI · 1997 to 2018
$4.8M
Intraoperative real time breast cancer margin assessment with nonlinear microscopR01CA178636 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CONNOLLY, JAMES, FUJIMOTO, JAMES G · 2013 to 2018
$1.7M
NCI NIH HHS R01 CA075289NCI NIH HHS R01 CA178636NEI NIH HHS R01 EY011289
6 · The paper itself

Abstract

Radiofrequency ablation (RFA) is widely used for the eradication of dysplasia and the treatment of early stage esophageal carcinoma in patients with Barrett’s esophagus (BE). However, there are several factors, such as variation of BE epithelium (EP) thickness among individual patients and varying RFA catheter-tissue contact, which may compromise RFA efficacy. We used a high-speed optical coherence tomography (OCT) system to identify and monitor changes in the esophageal tissue architecture from RFA. Two different OCT imaging/RFA application protocols were performed using an <italic<ex vivo</italic< swine esophagus model: (1) post-RFA volumetric OCT imaging for quantitative analysis of the coagulum formation using RFA applications with different energy settings, and (2) M-mode OCT imaging for monitoring the dynamics of tissue architectural changes in real time during RFA application. Post-RFA volumetric OCT measurements showed an increase in the coagulum thickness with respect to the increasing RFA energies. Using a subset of the specimens, OCT measurements of coagulum and coagulum + residual EP thickness were shown to agree with histology, which accounted for specimen shrinkage during histological processing. In addition, we demonstrated the feasibility of OCT for real-time visualization of the architectural changes during RFA application with different energy settings. Results suggest feasibility of using OCT for RFA treatment planning and guidance.

Indexed as

Tomography, Optical CoherenceCatheter AblationEsophageal NeoplasmsEsophagoscopyHumansTreatment Outcome

Identifiers

PMID28687822
PMCPMC5499807

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.