ArticleJournal of biomedical optics2017
Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography.
Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Optical coherence tomography imaging demonstrates endolymphatic hydrops in the lateral and posterior semicircular canals in noise-exposed mice.Hearing research · 2025Article
- Human inner ear fluid imbalance detected by optical coherence tomography correlates with hearing loss.Science translational medicine · 2025Article
- RotaRod and acoustic startle reflex performance of two potential mouse models for Meniere's disease.The European journal of neuroscience · 2023Article
- The Effect of Endolymphatic Hydrops and Mannitol Dehydration Treatment on Guinea Pigs.Frontiers in cellular neuroscience · 2022Article
- In Vivo Cochlear imaging provides a tool to study endolymphatic hydrops.Journal of vestibular research : equilibrium & orientation · 2021Article
- Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography.Quantitative imaging in medicine and surgery · 2019Review
- Endoscopic optical coherence tomography enables morphological and subnanometer vibratory imaging of the porcine cochlea through the round window.Optics letters · 2018Article
- ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography.Biomedical optics express · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Diseases that cause hearing loss and/or vertigo in humans such as Meniere’s disease are often studied using animal models. The volume of endolymph within the inner ear varies with these diseases. Here, we used a mouse model of increased endolymph volume, endolymphatic hydrops, to develop a computer-aided objective approach to measure endolymph volume from images collected <italic<in vivo</italic< using optical coherence tomography. The displacement of Reissner’s membrane from its normal position was measured in cochlear cross sections. We validated our computer-aided measurements with manual measurements and with trained observer labels. This approach allows for computer-aided detection of endolymphatic hydrops in mice, with test performance showing sensitivity of 91% and specificity of 87% using a running average of five measurements. These findings indicate that this approach is accurate and reliable for classifying endolymphatic hydrops and quantifying endolymph volume.
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