ArticleScientific reports2017
Human Cochlear Histopathology Reflects Clinical Signatures of Primary Neural Degeneration.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Evaluation of Spiral Ganglion Lesions by Electrophysiological Measures.Brain sciences · 2026Article
- High resolution, contrast-enhanced X-ray microscopy of theFrontiers in neuroscience · 2026Article
- Engineering of functional auditory neurons from human induced pluripotent stem cells.Military Medical Research · 2026Article
- Neural stem cell-loaded biohybrid hydrogel improves cochlear implants by electrode-neural coupling and neural regeneration.Theranostics · 2026Article
- Role of CSF flow and meningeal barriers in the development of inflammatory lesions at the CNS-PNS transition zone of cranial nerves in autoimmune demyelinating diseases.Acta neuropathologica · 2025Article
- A Retrospective Comparative Chart Review of Hearing Recovery in Neural and Sensory Type Sudden Sensorineural Hearing Loss Patients.The Journal of laryngology and otology · 2024Article
- Understanding the impact of modiolus porosity on stimulation of spiral ganglion neurons by cochlear implants.Scientific reports · 2024Article
- Parameterisation and Prediction of Intra-canal Cochlear Structures.Annals of biomedical engineering · 2024Article
- Peripheral neural synchrony in post-lingually deafened adult cochlear implant users.medRxiv : the preprint server for health sciences · 2024Article
- Insights Into Electrophysiological Metrics of Cochlear Health in Cochlear Implant Users Using a Computational Model.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Electrically evoked compound action potentials in cochlear implant users with preoperative residual hearing.Frontiers in human neuroscience · 2023Article
- [Mitochondrial encephalomyopathy involves ophthalmology otorhinolaryngology neurology and their clinical features].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Article
- Neural Tissue Degeneration in Rosenthal's Canal and Its Impact on Electrical Stimulation of the Auditory Nerve by Cochlear Implants: An Image-Based Modeling Study.International journal of molecular sciences · 2020Article
- Literature Review on the Distribution of Spiral Ganglion Cell Bodies inside the Human Cochlear Central Modiolar Trunk.The journal of international advanced otology · 2020Review
- Imaging hair cells through laser-ablated cochlear bone.Biomedical optics express · 2019Article
- Why Pre-Curved Modiolar Hugging Electrodes Only Cover The Basal Turn of The Cochlea and Not Beyond that?The journal of international advanced otology · 2018Article
- Direct Reprogramming of Spiral Ganglion Non-neuronal Cells into Neurons: Toward Ameliorating Sensorineural Hearing Loss by Gene Therapy.Frontiers in cell and developmental biology · 2018Article
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5 authors.
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Abstract
Auditory neuropathy is a significant and understudied cause of human hearing loss, diagnosed in patients who demonstrate abnormal function of the cochlear nerve despite typical function of sensory cells. Because the human inner ear cannot be visualized during life, histopathological analysis of autopsy specimens is critical to understanding the cellular mechanisms underlying this pathology. Here we present statistical models of severe primary neuronal degeneration and its relationship to pure tone audiometric thresholds and word recognition scores in comparison to age-matched control patients, spanning every decade of life. Analysis of 30 ears from 23 patients shows that severe neuronal loss correlates with elevated audiometric thresholds and poor word recognition. For each ten percent increase in total neuronal loss, average thresholds across patients at each audiometric test frequency increase by 6.0 dB hearing level (HL). As neuronal loss increases, threshold elevation proceeds more rapidly in low audiometric test frequencies than in high frequencies. Pure tone average closely agrees with word recognition scores in the case of severe neural pathology. Histopathologic study of the human inner ear continues to emphasize the need for non- or minimally invasive clinical tools capable of establishing cellular-level diagnoses.
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