ArticleScientific reports2017
Nuclear receptors connect progenitor transcription factors to cell cycle control.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Expanding the fly eye gene regulatory network: From Drosophila to the hoverfly Episyrphus balteatus.PLoS genetics · 2026Article
- Feedback control of organ size precision is mediated by BMP2-regulated apoptosis in the Drosophila eye.PLoS biology · 2024Article
- Combined inactivation of RB and Hippo converts differentiating Drosophila photoreceptors into eye progenitor cells through derepression of homothorax.Developmental cell · 2023Article
- A single-cell transcriptomic atlas characterizes the silk-producing organ in the silkworm.Nature communications · 2022Article
- Benchmarking of ATAC Sequencing Data From BGI's Low-Cost DNBSEQ-G400 Instrument for Identification of Open and Occupied Chromatin Regions.Frontiers in molecular biosciences · 2022Article
- Variation in Pleiotropic Hub Gene Expression Is Associated with Interspecific Differences in Head Shape and Eye Size in Drosophila.Molecular biology and evolution · 2021Article
- New regulators of Drosophila eye development identified from temporal transcriptome changes.Genetics · 2021Article
- Next-Generation Sequencing Reveals Increased Anti-oxidant Response and Ecdysone Signaling in STAT Supercompetitors inG3 (Bethesda, Md.) · 2019Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The specification and growth of organs is controlled simultaneously by networks of transcription factors. While the connection between these transcription factors with fate determinants is increasingly clear, how they establish the link with the cell cycle is far less understood. Here we investigate this link in the developing Drosophila eye, where two transcription factors, the MEIS1 homologue hth and the Zn-finger tsh, synergize to stimulate the proliferation of naïve eye progenitors. Experiments combining transcriptomics, open-chromatin profiling, motif analysis and functional assays indicate that these progenitor transcription factors exert a global regulation of the proliferation program. Rather than directly regulating cell cycle genes, they control proliferation through an intermediary layer of nuclear receptors of the ecdysone/estrogen-signaling pathway. This regulatory subnetwork between hth, tsh and nuclear receptors might be conserved from Drosophila to mammals, as we find a significant co-overexpression of their human homologues in specific cancer types.
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