ArticleScientific reports2017
Association between BRAF V600E Mutation and Ultrasound Features in Papillary Thyroid Carcinoma Patients with and without Hashimoto's Thyroiditis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Association between Hashimoto thyroiditis and clinical outcomes of papillary thyroid carcinoma: A meta-analysis.PloS one · 2022Pooled it
- Nomogram model based on ultrasonography and contrast-enhanced CT for predicting BRAFFrontiers in endocrinology · 2025Article
- CT-based texture analysis predicts BRAFFrontiers in oncology · 2025Article
- Ultrasound features as predictive markers ofGland surgery · 2024Article
- Associations of BRAFPediatric radiology · 2024Article
- Retrospective study of BRAFPeerJ · 2024Article
- Association of Ultrasonography Features of Follicular Thyroid Carcinoma With Tumor Invasiveness and Prognosis Based on WHO Classification and TERT Promoter Mutation.Korean journal of radiology · 2024Article
- Differential diagnosis of diffuse sclerotic thyroid papillary carcinoma and Hashimoto's thyroiditis using fine-needle aspiration cytology, BRAFJournal of clinical ultrasound : JCU · 2022Article
- [Correlation of conventional ultrasound features and related factors with BRAFV600E gene mutation in papillary thyroid carcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Article
- Higher EU-TIRADS-Score Correlated with BRAF V600E Positivity in the Early Stage of Papillary Thyroid Carcinoma.Journal of clinical medicine · 2021Article
- Correlation of ThyroSeq Results with Surgical Histopathology in Cytologically Indeterminate Thyroid Nodules.Endocrine pathology · 2020Article
- BRAFAfrican health sciences · 2020Article
- Prevalence ofGland surgery · 2020Review
- Correlations between Molecular Landscape and Sonographic Image of Different Variants of Papillary Thyroid Carcinoma.Journal of clinical medicine · 2019Review
- BRAFCancer medicine · 2019Article
- Massive hemoptysis: an unusual presentation of papillary thyroid carcinoma due to tracheal invasion.BMJ case reports · 2019Article
- Clinical impact of a cytological screening system using cyclin D1 immunostaining and genomic analysis for the diagnosis of thyroid nodules.BMC cancer · 2019Article
- Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies.Endocrinology and metabolism (Seoul, Korea) · 2018Article
- Mutational Profile of Papillary Thyroid Carcinoma in an Endemic Goiter Region of North India.Indian journal of endocrinology and metabolismArticle
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess the association between BRAF V600E mutation and ultrasound (US) features in papillary thyroid carcinoma (PTC) patients with and without Hashimoto's thyroiditis (HT). We retrospectively reviewed the US features and status of BRAF V600E mutation in 438 consecutive patients with surgically confirmed PTCs. The association between BRAF mutation and US features were analyzed. In addition, we conducted subgroup analyses in terms of coexistent HT. The BRAF mutation was found in 86.5% of patients (379 of 438). Patient age (OR: 1.028, P = 0.010), age ≥ 50 y (OR: 1.904, P = 0.030), and microcalcification (OR: 2.262, P = 0.015) on US were significantly associated with BRAF mutation in PTC patients. Solid component (OR: 5.739, P = 0.019) on US was the significant predictor for BRAF mutation in patients with HT, while age (OR: 1.036, P = 0.017) and microcalcification (OR: 3.093, P = 0.017) were significantly associated with BRAF mutation in patients without HT. In conclusion, older age and microcalcification are risk factors for BRAF mutation in PTC patients, especially in those without HT. For those with HT, however, PTCs with BRAF mutation tend to be solid on ultrasound. These factors might be considered when making treatment planning or prognosis evaluation.
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