Evidence map›Paper›PMID 28687722›Full record

SynthesisNeurology2017

A meta-analysis on progressive atrophy in intractable temporal lobe epilepsy: Time is brain?

Lorenzo Caciagli, Andrea Bernasconi, Samuel Wiebe, Matthias J Koepp, Neda Bernasconi, Boris C Bernhardt

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 3 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 3 syntheses or guidelines pooled it, 158 citations in OpenAlex.

  1. Pooled it
  2. Cerebellar Degeneration in Epilepsy: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  3. Epilepsy and syphilis: A systematic review and meta-analysis.Indian journal of dermatology, venereology and leprology
    Pooled it
  4. Review
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  10. Review
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  17. Observational
  18. Review
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lorenzo CaciagliFrom the Neuroimaging of Epilepsy Laboratory (L.C., A.B., N.B., B.C.B.) and Multimodal Imaging and Connectome Analysis Laboratory (B.C.B.), Montreal Neurological Institute and Hospital, McGill University; Department of Clinical Neurosciences (S.W.), University of Calgary, Canada; and Department of Clinical and Experimental Epilepsy (L.C., M.J.K.), UCL Institute of Neurology, London, UK.
Andrea BernasconiFrom the Neuroimaging of Epilepsy Laboratory (L.C., A.B., N.B., B.C.B.) and Multimodal Imaging and Connectome Analysis Laboratory (B.C.B.), Montreal Neurological Institute and Hospital, McGill University; Department of Clinical Neurosciences (S.W.), University of Calgary, Canada; and Department of Clinical and Experimental Epilepsy (L.C., M.J.K.), UCL Institute of Neurology, London, UK.
Samuel WiebeFrom the Neuroimaging of Epilepsy Laboratory (L.C., A.B., N.B., B.C.B.) and Multimodal Imaging and Connectome Analysis Laboratory (B.C.B.), Montreal Neurological Institute and Hospital, McGill University; Department of Clinical Neurosciences (S.W.), University of Calgary, Canada; and Department of Clinical and Experimental Epilepsy (L.C., M.J.K.), UCL Institute of Neurology, London, UK.
Matthias J KoeppFrom the Neuroimaging of Epilepsy Laboratory (L.C., A.B., N.B., B.C.B.) and Multimodal Imaging and Connectome Analysis Laboratory (B.C.B.), Montreal Neurological Institute and Hospital, McGill University; Department of Clinical Neurosciences (S.W.), University of Calgary, Canada; and Department of Clinical and Experimental Epilepsy (L.C., M.J.K.), UCL Institute of Neurology, London, UK.
Neda BernasconiFrom the Neuroimaging of Epilepsy Laboratory (L.C., A.B., N.B., B.C.B.) and Multimodal Imaging and Connectome Analysis Laboratory (B.C.B.), Montreal Neurological Institute and Hospital, McGill University; Department of Clinical Neurosciences (S.W.), University of Calgary, Canada; and Department of Clinical and Experimental Epilepsy (L.C., M.J.K.), UCL Institute of Neurology, London, UK.
Boris C BernhardtFrom the Neuroimaging of Epilepsy Laboratory (L.C., A.B., N.B., B.C.B.) and Multimodal Imaging and Connectome Analysis Laboratory (B.C.B.), Montreal Neurological Institute and Hospital, McGill University; Department of Clinical Neurosciences (S.W.), University of Calgary, Canada; and Department of Clinical and Experimental Epilepsy (L.C., M.J.K.), UCL Institute of Neurology, London, UK. boris.bernhardt@mcgill.ca.
University of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIt remains unclear whether drug-resistant temporal lobe epilepsy (TLE) is associated with cumulative brain damage, with no expert consensus and no quantitative syntheses of the available evidence.

methodsWe conducted a systematic review and meta-analysis of MRI studies on progressive atrophy, searching PubMed and Ovid MEDLINE databases for cross-sectional and longitudinal quantitative MRI studies on drug-resistant TLE.

resultsWe screened 2,976 records and assessed eligibility of 248 full-text articles. Forty-two articles met the inclusion criteria for quantitative evaluation. We observed a predominance of cross-sectional studies, use of different clinical indices of progression, and high heterogeneity in age-control procedures. Meta-analysis of 18/1 cross-sectional/longitudinal studies on hippocampal atrophy (n = 979 patients) yielded a pooled effect size of

conclusionsWhile the neuroimaging literature is overall suggestive of progressive atrophy in drug-resistant TLE, published studies have employed rather weak designs to directly demonstrate it. Longitudinal multicohort studies are needed to unequivocally differentiate aging from disease progression.

Indexed as

AtrophyBrainDisease ProgressionDrug Resistant EpilepsyEpilepsy, Temporal LobeHumansMagnetic Resonance Imaging

Identifiers

PMID28687722
PMCPMC5539734
OpenAlexW2731789640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.