ArticleEBioMedicine2017
Prognostic and Predictive Value of p21-activated Kinase 6 Associated Support Vector Machine Classifier in Gastric Cancer Treated by 5-fluorouracil/Oxaliplatin Chemotherapy.
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Article in EBioMedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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30citing papers in PubMed, 1 pooled it
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Artificial intelligence in gastric cancer: a systematic review.Journal of cancer research and clinical oncology · 2020Pooled it
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- Construction of a prognostic model for colorectal cancer based on clinical parameters and quantitative body composition using CT imaging.BMC medical imaging · 2026Article
- Stemness-based gastric cancer classification by machine learning for precision diagnosis and treatment of gastric cancer.Journal of gastrointestinal oncology · 2025Article
- Artificial intelligence and anti-cancer drugs' response.Acta pharmaceutica Sinica. B · 2025Review
- Computational Identification and Anti-Inflammatory Evaluation of T19093 as a TLR4/MD2 Inhibitor.Current topics in medicinal chemistry · 2025Article
- Targeting P21-activated kinase suppresses proliferation and enhances chemosensitivity in T-cell lymphoblastic lymphoma.Blood science (Baltimore, Md.) · 2023Article
- Early prediction of response to palliative chemotherapy in patients with stage-IV gastric and esophageal cancer.BMC cancer · 2023Article
- Gene signature developed for predicting early relapse and survival in early-stage pancreatic cancer.BJS open · 2023Article
- Cancerous inhibitor of protein phosphatase 2A enhances chemoresistance of gastric cancer cells to oxaliplatin.World journal of gastrointestinal oncology · 2023Article
- Hyperactivation of p21-Activated Kinases in Human Cancer and Therapeutic Sensitivity.Biomedicines · 2023Review
- AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA.Cell death & disease · 2022Article
- Review
- Review
- PAK6 promotes homologous-recombination to enhance chemoresistance to oxaliplatin through ATR/CHK1 signaling in gastric cancer.Cell death & disease · 2022Article
- Non-invasive measurement of tumor immune microenvironment and prediction of survival and chemotherapeutic benefits fromFrontiers in immunology · 2022Article
- Editorial: The use of chemotherapy in treating gastric cancers.Frontiers in oncology · 2022Article
- Construction of a 5-feature gene model by support vector machine for classifying osteoporosis samples.Bioengineered · 2021Article
- miR-1253, a novel tumor suppressor gene in colon cancer, is associated with poor patients prognosis.Clinical and experimental medicine · 2021Article
- Septicemic Melioidosis Detection Using Support Vector Machine with Five Immune Cell Types.Disease markers · 2021Article
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Authors and funding
18 authors at 3 institutions in 2 countries.
Yuming JiangDepartment of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, China; Guangdong Key Laboratory of Liver Disease Research, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Wei LiuGuangdong Key Laboratory of Liver Disease Research, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; Department of Hepatic Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Tuanjie LiDepartment of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, China.
Yanfeng HuDepartment of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, China.
Sile ChenDepartment of Gastrointestinal Surgery of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510700, Guangdong, China.
Sujuan XiGuangdong Key Laboratory of Liver Disease Research, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; Department of Infectious disease, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yajia WenGuangdong Key Laboratory of Liver Disease Research, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; Department of Infectious disease, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Lei HuangGerman Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Liying ZhaoDepartment of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, China.
Cuicui XiaoGuangdong Key Laboratory of Liver Disease Research, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; Department of Hepatic Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xiaohui HuangGuangdong Key Laboratory of Liver Disease Research, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Zhen HanDepartment of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, China.
Hao LiuDepartment of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, China.
Xiaolong QiDepartment of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, China.
Yang YangGuangdong Key Laboratory of Liver Disease Research, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; Department of Hepatic Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Jiang YuDepartment of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, China. Electronic address: balbc@163.com.
Shirong CaiDepartment of Gastrointestinal Surgery of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510700, Guangdong, China. Electronic address: caishirong@yeah.net.
Guoxin LiDepartment of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, China. Electronic address: gzliguoxin@163.com.
Sun Yat-sen University · CNNanfang Hospital · CNGerman Cancer Research Center · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine whether p21-activated Kinase (PAK) 6 is a prognostic and predictive marker in gastric cancer (GC) and to construct a classifier that can identify a subset of patients who are highly sensitive to 5-fluorouracil/oxaliplatin chemotherapy. We retrospectively analyzed the expression levels of PAK6, cyclooxygenase 2, p21
Indexed as
Drug Resistance, NeoplasmUp-RegulationCyclin-Dependent Kinase Inhibitor p21Cyclooxygenase 2DNA-Binding ProteinsEndonucleasesFemaleFluorouracilGene Expression Regulation, NeoplasticHumansKi-67 AntigenMaleOrganoplatinum CompoundsOxaliplatinp21-Activated KinasesPredictive Value of TestsCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21Cyclooxygenase 2DNA-Binding ProteinsEndonucleasesERCC1 protein, humanFluorouracilKi-67 AntigenOrganoplatinum CompoundsOxaliplatinp21-Activated KinasesPAK6 protein, humanPTGS2 protein, humanThymidylate Synthase5-FU/oxaliplatin chemotherapyGastric cancerNomogramp21-activated kinase 6SVM classifier
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.