Evidence map›Paper›PMID 28687077›Full record

ArticleCardiovascular diabetology2017

Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia.

Louis A Saddic, Sarah M Nicoloro, Olga T Gupta, Michael P Czech, Joshua Gorham, Stanton K Shernan, Christine E Seidman, Jon G Seidman, Sary F Aranki, Simon C Body and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00985049 (Whole Genome Expression of Left Ventricular Myocardium During Cardiac Surgery), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00985049 recruitingnot on this map

Whole Genome Expression of Left Ventricular Myocardium During Cardiac Surgery

TypeobservationalSponsorBrigham and Women's HospitalRan2009 to 2025Enrolled350ConditionsCardiovascular Diseases
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
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  6. Observational
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Louis A SaddicDepartment of Anesthesiology and Perioperative Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Sarah M NicoloroProgram in Molecular Medicine, University of Massachusetts Medical Center, Worcester, MA, USA.
Olga T GuptaUT Southwestern Medical Center, Dallas, TX, USA.
Michael P CzechProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Joshua GorhamDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Stanton K ShernanDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, CWN L1, 75 Francis Street, Boston, MA, 02115, USA.
Christine E SeidmanDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Howard Hughes Medical Institute, Boston, MA, 02115, USA.
Jon G SeidmanDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Sary F ArankiDivision of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Simon C BodyDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, CWN L1, 75 Francis Street, Boston, MA, 02115, USA.
Timothy P FitzgibbonsCardiovascular Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Jochen D MuehlschlegelDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, CWN L1, 75 Francis Street, Boston, MA, 02115, USA. jmuehlschlegel@partners.org.ORCID 0000-0002-6209-7253
Brigham and Women's Hospital · USUniversity of Massachusetts Chan Medical School · USHarvard University · USSouthwestern Medical Center · USUniversity of California, Los Angeles · US

Funding

Insulin Signaling and Metabolic Regulation in AdipocytesR37DK030898 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 1996 to 2021
$7.2M
Insulin Signaling and Metabolic Regulation in AdipocytesR01DK030898 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 1986 to 2011
$2.7M
Genetics of gene expression in human left ventricular myocardiumR01HL118266 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MUEHLSCHLEGEL, JOCHEN DANIEL · 2013 to 2017
$2.3M
NHLBI NIH HHS R01 HL118266NIDDK NIH HHS R01 DK030898NIDDK NIH HHS R37 DK030898
6 · The paper itself

Abstract

backgroundOmentin-1, also known as Intelectin-1 (ITLN1), is an adipokine with plasma levels associated with diabetes, obesity, and coronary artery disease. Recent studies suggest that ITLN1 can mitigate myocardial ischemic injury but the expression of ITLN1 in the heart itself has not been well characterized. The purpose of this study is to discern the relationship between the expression pattern of ITLN1 RNA in the human heart and the level of circulating ITLN1 protein in plasma from the same patients following myocardial ischemia.

methodsA large cohort of patients (n = 140) undergoing elective cardiac surgery for aortic valve replacement were enrolled in this study. Plasma and left ventricular biopsy samples were taken at the beginning of cardiopulmonary bypass and after an average of 82 min of ischemic cross clamp time. The localization of ITLN1 in epicardial adipose tissue (EAT) was also further characterized with immunoassays and cell fate transition studies.

resultsmRNA expression of ITLN1 decreases in left ventricular tissue after acute ischemia in human patients (mean difference 280.48, p = 0.001) whereas plasma protein levels of ITLN1 increase (mean difference 5.24, p < 0.001). Immunohistochemistry localized ITLN1 to the mesothelium or visceral pericardium of EAT. Epithelial to mesenchymal transition in mesothelial cells leads to a downregulation of ITLN1 expression.

conclusionsMyocardial injury leads to a decrease in ITLN1 expression in the heart and a corresponding increase in plasma levels. These changes may in part be due to an epithelial to mesenchymal transition of the cells that express ITLN1 following ischemia. Trial Registration Clinicaltrials.gov ID: NCT00985049.

Indexed as

AdipokinesAdipose TissueAgedAged, 80 and overAortic ValveCoronary Artery DiseaseCytokinesEpithelial-Mesenchymal TransitionFemaleGPI-Linked ProteinsHumansLectinsMaleMiddle AgedMyocardial IschemiaPericardiumAdipokinesCytokinesGPI-Linked ProteinsITLN1 protein, humanLectinsAdipokineCardiovascularIschemiaOmentinRNA-seq

Identifiers

PMID28687077
PMCPMC5501278
OpenAlexW2732309961

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.