ArticleCell stem cell2017
Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity.
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Article in Cell stem cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 231 papers.
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231citing papers in PubMed
20.7field-weighted citation impact, top 1% of its field
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Who cites it
231 citing papers in PubMed, 361 citations in OpenAlex.
- Stemness in Colon Cancer.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Paneth cell-derived Notch ligands DLL1 and DLL4 are crucial for intestinal crypt base stem cells.bioRxiv : the preprint server for biology · 2026Article
- Building and regenerating intestines by manipulating intestinal stem cells.Nature reviews. Gastroenterology & hepatology · 2026Review
- Dietary Regulation of Intestinal Stem Cell Function: Nutrient-Sensing, Microbiota-Mediated, and Regenerative Mechanisms from a Dietetic Perspective.Biomedicines · 2026Review
- Melatonin-inspired hybrid spheroids accelerate intestinal repair via YAP-driven fetal reprogramming.Asian journal of pharmaceutical sciences · 2026Article
- Fasting primes small intestinal regeneration after damage via a microbiome-metabolite-chromatin axis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease.MedComm · 2026Article
- Aged differentiated cells reverse into native stemness-like state by niche cytokines to sustain lifelong homeostasis and tissue repair.Nature communications · 2026Article
- IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation.Nature communications · 2026Article
- Immunohistochemical investigation of the transcription factor PROX1 emphasizing on neuroendocrine neoplasms.Medical molecular morphology · 2026Article
- Plasticity and stringency: rethinking stem cell division modes.Biochemical Society transactions · 2026Review
- Dose- and Time-Dependent Effects of Cobalt Chloride Supplementation on Growth Performance and Intestinal Development in Weaned Piglets.Animals : an open access journal from MDPI · 2026Article
- Fetal reversion from diverse lineages sustains the intestinal stem cell pool and confers stress resilience.Communications biology · 2026Article
- Cell phenotypic conversion and fate change during the host defense response, tissue injury and repair.Pharmacology & therapeutics · 2026Review
- Maternal Organ Growth: How the Adult Intestine Remodels During Pregnancy and Lactation.Development, growth & differentiation · 2026Review
- A Multipotent PROX1+ Tumor Stem/Progenitor Cell Population Emerges during Intestinal Tumorigenesis and Mediates Radioresistance in Colorectal Cancer.Cancer research · 2025Article
- Lgr5+ Stem Cells Maintain Apex Position in Cell Hierarchy of the Intestinal Epithelium During Homeostasis and Injury.bioRxiv : the preprint server for biology · 2025Article
- Organ-Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming.Aging cell · 2025Review
- Unraveling enteroendocrine cell lineage dynamics and associated gene regulatory networks during intestinal development.Biology open · 2025Article
- Injury-induced intestinal stem cell renewal requires capillary morphogenesis gene 2.EMBO molecular medicine · 2025Article
171 more citing papers are in PubMed but not listed here.
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Authors and funding
46 authors at 13 institutions in 1 country.
Kelley S YanDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Columbia Center for Human Development, Columbia Stem Cell Initiative, Department of Medicine, Division of Digestive and Liver Diseases, Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.
Olivier GevaertDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Grace X Y Zheng10x Genomics, Inc., Pleasanton, CA 94566, USA.
Benedict AnchangDepartment of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Christopher S ProbertDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kathryn A LarkinDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Paige S DaviesOregon Health & Science University, Department of Cell, Developmental and Cancer Biology, Portland, OR 97239, USA.
Zhuan-Fen ChengDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
John S KaddisDepartment of Diabetes and Cancer Discovery Science, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Arnold HanDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Columbia Center for Translational Immunology, Department of Medicine, Division of Digestive and Liver Diseases, Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
Kelly RoelfDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ruben I CalderonColumbia Center for Human Development, Columbia Stem Cell Initiative, Department of Medicine, Division of Digestive and Liver Diseases, Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.
Esther CynnColumbia Center for Human Development, Columbia Stem Cell Initiative, Department of Medicine, Division of Digestive and Liver Diseases, Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.
Xiaoyi HuColumbia Center for Human Development, Columbia Stem Cell Initiative, Department of Medicine, Division of Digestive and Liver Diseases, Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.
Komal MandleywalaColumbia Center for Human Development, Columbia Stem Cell Initiative, Department of Medicine, Division of Digestive and Liver Diseases, Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.
Julie WilhelmyDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sue M GrimesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
David C CorneyDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stéphane C Boutet10x Genomics, Inc., Pleasanton, CA 94566, USA.
Jessica M Terry10x Genomics, Inc., Pleasanton, CA 94566, USA.
Phillip Belgrader10x Genomics, Inc., Pleasanton, CA 94566, USA.
Solongo B Ziraldo10x Genomics, Inc., Pleasanton, CA 94566, USA.
Tarjei S Mikkelsen10x Genomics, Inc., Pleasanton, CA 94566, USA.
Fengchao WangStowers Institute for Medical Research, Kansas City, MO 64110, USA.
Richard J von FurstenbergDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Nicholas R SmithOregon Health & Science University, Department of Cell, Developmental and Cancer Biology, Portland, OR 97239, USA.
Parthasarathy ChandrakesanDepartment of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Randal MayDepartment of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Mary Ann S ChrissyDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rajan JainDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Christine A CartwrightDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Joyce C NilandDepartment of Diabetes and Cancer Discovery Science, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Young-Kwon HongDepartments of Surgery and of Biochemistry & Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Jill CarringtonNational Institutes of Health, Division of Digestive Diseases and Nutrition, NIDDK, Bethesda, MD 20892, USA.
David T BreaultDivision of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA.
Jonathan EpsteinDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Courtney W HouchenDepartment of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
John P LynchDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Martin G MartinDepartment of Pediatrics, Division of Gastroenterology and Nutrition, Mattel Children's Hospital and the David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Sylvia K PlevritisDepartment of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Christina CurtisDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Hanlee P JiDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Linheng LiStowers Institute for Medical Research, Kansas City, MO 64110, USA.
Susan J HenningDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Melissa H WongOregon Health & Science University, Department of Cell, Developmental and Cancer Biology, Portland, OR 97239, USA.
Calvin J KuoDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: cjkuo@stanford.edu.
Stanford University · US10X Genomics (United States) · USColumbia University Irving Medical Center · USUniversity of Pennsylvania · USOregon Health & Science University · USUniversity of Oklahoma Health Sciences Center · USCity of Hope · USStowers Institute for Medical Research · USUniversity of North Carolina at Chapel Hill · USBoston Children's Hospital · USMattel Children's Hospital · USNational Institutes of Health · USUniversity of Southern California · US
Funding
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JERROLD R. TURNER · 1986 to 2026
$32.4MSYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2MNUTRITIONT32DK007647 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anthony W Ferrante, Lori M Zeltser · 1990 to 2026
$7.4MRegulation of actively proliferating and quiescent intestinal stem cellsU01DK085527 · NIDDK · STANFORD UNIVERSITY · PI KUO, CALVIN J · 2009 to 2023
$6.9MIntestinal Stem Cell Consortium Coordinating CenterU01DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2009 to 2018
$6.5MIsolation and Characterization of Intestinal Stem CellsU01DK085507 · NIDDK · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI LI, LINHENG · 2009 to 2023
$6.2MIntestinal Stem Cell Culture and Entero-Endocrine Lineage DevelopmentU01DK085535 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUNN, JAMES C, MARTIN, MARTIN G · 2009 to 2018
$3.7MTranslating Intestinal Radioprotection by EGLN Inhibition to Improve Clinical Outcomes in Unresectable Pancreatic CancerR01CA227517 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KOONG, ALBERT · 2019 to 2023
$2.3MLimited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating CenterU24DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2019 to 2023
$2.3MRadiogenomics Framework for Non-Invasive Personalized MedicineR01EB020527 · NIBIB · STANFORD UNIVERSITY · PI GEVAERT, OLIVIER · 2015 to 2018
$2.3MCharacterization of Telomerase Expressing Intestinal Stem CellsR01DK084056 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI BREAULT, DAVID T · 2010 to 2015
$2.2MThe Intestinal Stem Cell NicheU01DK085551 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LYNCH, JOHN P., RUSTGI, ANIL K · 2009 to 2014
$2.1MNCI NIH HHS R01 CA227517NHLBI NIH HHS K08 HL119553NIBIB NIH HHS R01 EB020527NICHD NIH HHS P30 HD018655NIDDK NIH HHS K08 DK096048NIDDK NIH HHS K08 DK100739NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK084056NIDDK NIH HHS R03 DK114656NIDDK NIH HHS T32 DK007647NIDDK NIH HHS U01 DK085507NIDDK NIH HHS U01 DK085508NIDDK NIH HHS U01 DK085525NIDDK NIH HHS U01 DK085527NIDDK NIH HHS U01 DK085532NIDDK NIH HHS U01 DK085535NIDDK NIH HHS U01 DK085547NIDDK NIH HHS U01 DK085551NIDDK NIH HHS U24 DK085532
Abstract
Several cell populations have been reported to possess intestinal stem cell (ISC) activity during homeostasis and injury-induced regeneration. Here, we explored inter-relationships between putative mouse ISC populations by comparative RNA-sequencing (RNA-seq). The transcriptomes of multiple cycling ISC populations closely resembled Lgr5
Indexed as
AnimalsAntigens, DifferentiationEnteroendocrine CellsGene Expression RegulationIntestinal MucosaJejunumMiceMice, TransgenicStem CellsAntigens, Differentiation
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