ArticleMagnetic resonance in medicine2018
A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 65 citations in OpenAlex.
- Toward Free-Breathing Renal CEST MRI: Preclinical Evaluation of a Novel Prospective Respiratory Triggering Approach.Magnetic resonance in medicine · 2026Article
- Investigation of Endogenous Renal CEST Contrast and the Influence of Respiratory Motion on a Clinical 3 Tesla MRI: An In Vivo and In Vitro Study.Magnetic resonance in medicine · 2026Article
- Transdermal bicarbonate buffer therapy increases intratumoral pH and elicits antitumor responses in bladder cancer.Frontiers in immunology · 2026Article
- Assessment of renal allograft function using amide proton transfer imaging.Frontiers in medicine · 2025Article
- Physics-guided multi-dimensional scan optimization and quasi-steady-state reconstruction to enhance CEST MRI sensitivity efficiency and quantification accuracy.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2025Article
- Quasi-steady-state (QUASS) reconstruction enhances TMagnetic resonance in medicine · 2024Article
- Recent nanotheranostic approaches in cancer research.Clinical and experimental medicine · 2024Review
- Clinically Translatable HyperpolarizedACS sensors · 2023Article
- Numerical simulation-based assessment of pH-sensitive chemical exchange saturation transfer MRI quantification accuracy across field strengths.NMR in biomedicine · 2023Article
- Detection of tissue pH with quantitative chemical exchange saturation transfer magnetic resonance imaging.NMR in biomedicine · 2023Review
- Acyl Hydrazides and Acyl Hydrazones as High-Performance Chemical Exchange Saturation Transfer MRI Contrast Agents.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Demonstration of accurate multi-pool chemical exchange saturation transfer MRI quantification - Quasi-steady-state reconstruction empowered quantitative CEST analysis.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2023Article
- Molecular MRI-Based Monitoring of Cancer Immunotherapy Treatment Response.International journal of molecular sciences · 2023Review
- Noninvasively differentiating acute and chronic nephropathies via multiparametric urea-CEST, nuclear Overhauser enhancement-CEST, and quantitative magnetization transfer MRI.Magnetic resonance in medicine · 2023Article
- Average saturation efficiency filter ASEF-CEST MRI of stroke rodents.Magnetic resonance in medicine · 2023Article
- In vivo pH mapping with omega plot-based quantitative chemical exchange saturation transfer MRI.Magnetic resonance in medicine · 2023Article
- Intraperitoneal Delivery of Iopamidol to Assess Extracellular pH of Orthotopic Pancreatic Tumor Model by CEST-MRI.Contrast media & molecular imaging · 2023Article
- Noninvasive assessment of renal dynamics and pH in a unilateral ureter obstruction model using DCE MR-CEST urography.Magnetic resonance in medicine · 2023Article
- Large Protein Assemblies for High-Relaxivity Contrast Agents: The Case of Gadolinium-Labeled Asparaginase.Bioconjugate chemistry · 2022Article
- Quasi-steady-state amide proton transfer (QUASS APT) MRI enhances pH-weighted imaging of acute stroke.Magnetic resonance in medicine · 2022Article
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6 authors at 4 institutions in 3 countries.
Funding
Abstract
purposeTo extend the pH detection range of iopamidol-based ratiometric chemical exchange saturation transfer (CEST) MRI at sub-high magnetic field and establish quantitative renal pH MRI.
methodsChemical exchange saturation transfer imaging was performed on iopamidol phantoms with pH of 5.5 to 8.0 and in vivo on rat kidneys (n = 5) during iopamidol administration at a 4.7 T. Iopamidol CEST effects were described using a multipool Lorentzian model. A generalized ratiometric analysis was conducted by ratioing resolved iopamidol CEST effects at 4.3 and 5.5 ppm obtained under 1.0 and 2.0 µT, respectively. The pH detection range was established for both the standard ratiometric analysis and the proposed resolved approach. Renal pH was mapped in vivo with regional pH assessed by one-way analysis of variance.
resultsGood-fitting performance was observed in multipool Lorentzian resolving of CEST effects (R
conclusionsThe proposed ratiometric approach extended the iopamidol pH detection range, enabling the renal pH mapping in vivo, which is promising for pH imaging studies at sub-high or low fields with potential clinical applicability. Magn Reson Med 79:1553-1558, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
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