ArticlePloS one2017
Examining the gender difference in the association between metabolic syndrome and the mean leukocyte telomere length.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- The association of metabolic syndrome with telomere length as a marker of cellular aging: a systematic review and meta-analysis.Frontiers in genetics · 2024Pooled it
- Association between metabolic syndrome and uric acid: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Telomere Length in Metabolic Syndrome: Mechanisms, Epidemiology and Clinical Implications: A Narrative Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Examining the relationship between cardiometabolic risk factors and telomere length in women: a systematic review.Innovation in aging · 2025Review
- The relationship between greenspace exposure and telomere length in the National Health and Nutrition Examination Survey.The Science of the total environment · 2023Article
- The consumption ofRedox report : communications in free radical research · 2023Article
- Metabolic syndrome and transaminases: systematic review and meta-analysis.Diabetology & metabolic syndrome · 2023Review
- The effect of metformin treatment on leukocyte telomere length in patients with polycystic ovary syndrome: a prospective case-control study.Journal of assisted reproduction and genetics · 2022Article
- Telomere and Telomerase: Biological Markers of Organic Vital Force State and Homeopathic Treatment Effectiveness.Homeopathy : the journal of the Faculty of Homeopathy · 2021Article
- Discrimination and Leukocyte Telomere Length by Depressive Symptomatology: The Jackson Heart Study.Healthcare (Basel, Switzerland) · 2021Article
- Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the Aging.Biology · 2021Review
- From culture to chromosomes: A mother-child dyadic study of acculturation, telomere lengths and body fat.Comprehensive psychoneuroendocrinology · 2021Article
- Association of leukocyte telomere length with metabolic syndrome in type 2 diabetes mellitus.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Gender Difference in Associations Between Telomere Length and Risk Factors in Patients With Stroke.Frontiers in aging neuroscience · 2021Article
- Genetically Increased Telomere Length and Aging-Related Traits in the U.K. Biobank.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Article
- Relationship between Decreased Serum Superoxide Dismutase Activity and Metabolic Syndrome: Synergistic Mediating Role of Insulin Resistance andOxidative medicine and cellular longevity · 2020Article
- The association of telomere length with substance use disorders: systematic review and meta-analysis protocol.Systematic reviews · 2019Article
- Relative Telomere Length and Cardiovascular Risk Factors.Biomolecules · 2019Article
- Association between prenatal particulate air pollution exposure and telomere length in cord blood: Effect modification by fetal sex.Environmental research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism of cellular aging likely involves decreased telomere length and is associated with age-related diseases such as cardiovascular disease. Metabolic syndrome (MetS) is an important risk factor for CVD. The purpose of this study was to investigate the association between LTL and MetS. We evaluated 7370 participants in the National Health and Nutrition Examination Survey (1999-2002). The association between LTL and individual MetS components and the number of MetS components was analyzed by multivariable regression models, adjusting for gender, race/ethnicity, albumin, C-reactive protein, alanine transaminase, uric acid and medical condition. An increase in the number of MetS components was strongly associated with shorter telomere length, especially in female participants (p for trend < 0.05). In addition, triglycerides were negatively associated with LTL in female participants (p < 0.001). Waist circumstance was associated with decreased LTL (p < 0.05) in both males and females. In summary, our study indicated that an increment of MetS component is strongly associated with shorter LTL, especially in the female population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.