ArticlePloS one2017
Estimating influenza and respiratory syncytial virus-associated mortality in Western Kenya using health and demographic surveillance system data, 2007-2013.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- The epidemiology of seasonal influenza after the 2009 influenza pandemic in Africa: a systematic review.African health sciences · 2020Pooled it
- Routine immunisation coverage in the context of seasonal influenza vaccine introduction for children in Nakuru and Mombasa counties in Kenya, 2019-21: an observational study.The Lancet. Global health · 2025Observational
- The National Burden of Influenza-Associated Respiratory Illness Among Children Aged <5 Years in Niger, 2015-2018.Influenza and other respiratory viruses · 2025Article
- The National Burden of Influenza-Associated Respiratory Illness Across Levels of Severity in Egypt, 2016-2019.Influenza and other respiratory viruses · 2024Article
- A Model-Based Estimation of RSV-Attributable Incidence of Hospitalizations and Deaths in Italy Between 2015 and 2019.Infectious diseases and therapy · 2024Article
- Estimation of Symptomatic Respiratory Syncytial Virus Infection Incidence in Adults in Multiple Countries: A Time-Series Model-Based Analysis Protocol.Infectious diseases and therapy · 2024Article
- Estimated Incidence of Hospitalizations and Deaths Attributable to Respiratory Syncytial Virus Infections Among Adults in Germany Between 2015 and 2019.Infectious diseases and therapy · 2024Article
- Estimates of the national burden of respiratory syncytial virus in Kenyan children aged under 5 years, 2010-2018.BMC medicine · 2023Article
- Incident changes in the prevalence of influenza virus during COVID-19 pandemic in Hangzhou, China.The clinical respiratory journal · 2022Article
- Longitudinal analyses suggest a higher burden of self-reported influenza-like illness among women and girls in a rural community in western Kenya.Global epidemiology · 2021Article
- Postmortem Study of Cause of Death Among Children Hospitalized With Respiratory Illness in Kenya.The Pediatric infectious disease journal · 2021Article
- Epidemiology and Seasonality of Childhood Respiratory Syncytial Virus Infections in the Tropics.Viruses · 2021Review
- Article
- Influenza-associated excess respiratory mortality in China, 2010-15: a population-based study.The Lancet. Public health · 2019Article
- Reply to Alonso et al. "Bangladesh and Rwanda: Cases of high burden of influenza in tropical countries?"Influenza and other respiratory viruses · 2018Article
- Burden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study.BMC infectious diseases · 2018Observational
- Overview of three influenza seasons in Georgia, 2014-2017.PloS one · 2018Article
- Article
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11 authors.
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Abstract
backgroundInfluenza and respiratory syncytial virus (RSV) associated mortality has not been well-established in tropical Africa.
methodsWe used the negative binomial regression method and the rate-difference method (i.e. deaths during low and high influenza/RSV activity months), to estimate excess mortality attributable to influenza and RSV using verbal autopsy data collected through a health and demographic surveillance system in Western Kenya, 2007-2013. Excess mortality rates were calculated for a) all-cause mortality, b) respiratory deaths (including pneumonia), c) HIV-related deaths, and d) pulmonary tuberculosis (TB) related deaths.
resultsUsing the negative binomial regression method, the mean annual all-cause excess mortality rate associated with influenza and RSV was 14.1 (95% confidence interval [CI] 0.0-93.3) and 17.1 (95% CI 0.0-111.5) per 100,000 person-years (PY) respectively; and 10.5 (95% CI 0.0-28.5) and 7.3 (95% CI 0.0-27.3) per 100,000 PY for respiratory deaths, respectively. Highest mortality rates associated with influenza were among ≥50 years, particularly among persons with TB (41.6[95% CI 0.0-122.7]); and with RSV were among <5 years. Using the rate-difference method, the excess mortality rate for influenza and RSV was 44.8 (95% CI 36.8-54.4) and 19.7 (95% CI 14.7-26.5) per 100,000 PY, respectively, for all-cause deaths; and 9.6 (95% CI 6.3-14.7) and 6.6 (95% CI 3.9-11.0) per 100,000 PY, respectively, for respiratory deaths.
conclusionsOur study shows a substantial excess mortality associated with influenza and RSV in Western Kenya, especially among children <5 years and older persons with TB, supporting recommendations for influenza vaccination and efforts to develop RSV vaccines.
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