ArticlePloS one2017
BIG LEAF is a regulator of organ size and adventitious root formation in poplar.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- miR172-AP2 Controls Age-Dependent Regeneration Competence in Populus.Plant biotechnology journal · 2026Article
- Article
- Role of Plant Growth Regulators in AdventitiousPlants (Basel, Switzerland) · 2025Article
- Discovery of genes that positively affect biomass and stress associated traits in poplar.Frontiers in plant science · 2024Article
- Molecular basis of differential adventitious rooting competence in poplar genotypes.Journal of experimental botany · 2022Article
- SlKIX8 and SlKIX9 are negative regulators of leaf and fruit growth in tomato.Plant physiology · 2022Article
- Comparative transcriptomic analysis uncovers conserved pathways involved in adventitious root formation in poplar.Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Adventitious Rooting inFrontiers in plant science · 2021Review
- CRISPR/Cas9-mediated single and biallelic knockout of poplar STERILE APETALA (PopSAP) leads to complete reproductive sterility.Plant biotechnology journal · 2021Article
- The bZIP53-IAA4 module inhibits adventitious root development in Populus.Journal of experimental botany · 2020Article
- Arabidopsis Leaf Flatness Is Regulated by PPD2 and NINJA through Repression ofPlant physiology · 2018Article
- Manipulation of Growth and Architectural Characteristics in Trees for Increased Woody Biomass Production.Frontiers in plant science · 2018Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we report the discovery through activation tagging and subsequent characterization of the BIG LEAF (BL) gene from poplar. In poplar, BL regulates leaf size via positively affecting cell proliferation. Up and downregulation of the gene led to increased and decreased leaf size, respectively, and these phenotypes corresponded to increased and decreased cell numbers. BL function encompasses the early stages of leaf development as native BL expression was specific to the shoot apical meristem and leaf primordia and was absent from the later stages of leaf development and other organs. Consistently, BL downregulation reduced leaf size at the earliest stages of leaf development. Ectopic expression in mature leaves resulted in continued growth most probably via sustained cell proliferation and thus the increased leaf size. In contrast to the positive effect on leaf growth, ectopic BL expression in stems interfered with and significantly reduced stem thickening, suggesting that BL is a highly specific activator of growth. In addition, stem cuttings from BL overexpressing plants developed roots, whereas the wild type was difficult to root, demonstrating that BL is a positive regulator of adventitious rooting. Large transcriptomic changes in plants that overexpressed BL indicated that BL may have a broad integrative role, encompassing many genes linked to organ growth. We conclude that BL plays a fundamental role in control of leaf size and thus may be a useful tool for modifying plant biomass productivity and adventitious rooting.
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