Evidence map›Paper›PMID 28686578›Full record

ArticleCell death and differentiation2017

Culling of APCs by inflammatory cell death pathways restricts TIM3 and PD-1 expression and promotes the survival of primed CD8 T cells.

Rajen Patel, Kwangsin Kim, Bojan Shutinoski, Kristina Wachholz, Lakshmi Krishnan, Subash Sad

Open access · bronzeAbstract read
In one paragraph

Article in Cell death and differentiation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rajen PatelDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Kwangsin KimDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Bojan ShutinoskiDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Kristina WachholzDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Lakshmi KrishnanDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Subash SadDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
University of Ottawa · CANational Research Council Canada · CA

Funding

Mechanisms of placental infection by food-borne pathogensR01AI101049 · NIAID · UNIVERSITY OF ROCHESTER · PI KRISHNAN, LAKSHMI, MURPHY, SHAWN P · 2012 to 2016
$2.1M
CIHRNIAID NIH HHS R01 AI101049
6 · The paper itself

Abstract

We evaluated the impact of premature cell death of antigen-presenting cells (APCs) by Caspase-1- and RipK3-signaling pathways on CD8

Indexed as

Cross-PrimingAnimalsAntigen-Presenting CellsCaspasesCD8-Positive T-LymphocytesCell DeathCell SurvivalDendritic CellsHepatitis A Virus Cellular Receptor 2InflammationInterleukin-1Mice, Inbred C57BLMitogen-Activated Protein KinasesNF-kappa BProgrammed Cell Death 1 ReceptorReceptor-Interacting Protein Serine-Threonine KinasesCaspasesHavcr2 protein, mouseHepatitis A Virus Cellular Receptor 2Interleukin-1Mitogen-Activated Protein KinasesNF-kappa BPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorReceptor-Interacting Protein Serine-Threonine KinasesRipk3 protein, mouse

Identifiers

PMID28686578
PMCPMC5635216
OpenAlexW2732715425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.