ArticleeLife2017
The cyanobacterial circadian clock follows midday in vivo and in vitro.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- From phenomenon to mechanism in the circadian clock of Synechococcus elongatus.Npj biological timing and sleep · 2026Review
- KaiC-dependent circadian positioning of RNA polymerase and ribosome in cyanobacteria.iScience · 2026Article
- Article
- The free-running property of circadian clocks is needed to tolerate changing photoperiods.Current biology : CB · 2026Article
- Environmental and molecular noise buffering by the cyanobacterial clock in individual cells.Nature communications · 2025Article
- Programming scheduled self-assembly of circadian materials.Nature communications · 2025Article
- Bacteria can anticipate the seasons: Photoperiodism in cyanobacteria.Science (New York, N.Y.) · 2024Article
- Bacteria can anticipate the seasons: photoperiodism in cyanobacteria.bioRxiv : the preprint server for biology · 2024Article
- Article
- Article
- Microbial circadian clocks: host-microbe interplay in diel cycles.BMC microbiology · 2023Review
- Circadian entrainment of in vitro reactions, in real time, and around the clock.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Synchronization of the circadian clock to the environment tracked in real time.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Evolution of self-sustained circadian rhythms is facilitated by seasonal change of daylight.Proceedings. Biological sciences · 2022Article
- KidA, a multi-PAS domain protein, tunes the period of the cyanobacterial circadian oscillator.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Reconstitution of an intact clock reveals mechanisms of circadian timekeeping.Science (New York, N.Y.) · 2021Article
- The circadian clock ensures successful DNA replication in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A Mechanistic Model of the Regulation of Division Timing by the Circadian Clock in Cyanobacteria.Biophysical journal · 2020Article
- Bayesian modeling reveals metabolite-dependent ultrasensitivity in the cyanobacterial circadian clock.Molecular systems biology · 2020Article
- Orchestration of Circadian Timing by Macromolecular Protein Assemblies.Journal of molecular biology · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Circadian rhythms are biological oscillations that schedule daily changes in physiology. Outside the laboratory, circadian clocks do not generally free-run but are driven by daily cues whose timing varies with the seasons. The principles that determine how circadian clocks align to these external cycles are not well understood. Here, we report experimental platforms for driving the cyanobacterial circadian clock both in vivo and in vitro. We find that the phase of the circadian rhythm follows a simple scaling law in light-dark cycles, tracking midday across conditions with variable day length. The core biochemical oscillator comprised of the Kai proteins behaves similarly when driven by metabolic pulses in vitro, indicating that such dynamics are intrinsic to these proteins. We develop a general mathematical framework based on instantaneous transformation of the clock cycle by external cues, which successfully predicts clock behavior under many cycling environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.