Evidence map›Paper›PMID 28686080›Full record

ArticlePharmacogenomics2017

Influence of common and rare genetic variation on warfarin dose among African-Americans and European-Americans using the exome array.

Nianjun Liu, Marguerite R Irvin, Degui Zhi, Amit Patki, T Mark Beasley, Deborah A Nickerson, Charles E Hill, Jinbo Chen, Stephen E Kimmel, Nita A Limdi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacogenomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Genomewide Association Studies in Pharmacogenomics.Clinical pharmacology and therapeutics · 2021
    Review
  5. Article
  6. Review
  7. Issues in the Use of Human Tissues to Support Precision Medicine.Journal of health care for the poor and underserved · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Nianjun LiuDepartment of Epidemiology & Biostatistics, School of Public Health - Bloomington, Indiana University, Bloomington, IN 47405, USA.
Marguerite R IrvinDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Degui ZhiSchool of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Amit PatkiDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
T Mark BeasleyDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Deborah A NickersonDepartment of Genome Sciences, School of Medicine, University of Washington, Seattle, WA 98195, USA.
Charles E HillDepartment of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Jinbo ChenDepartment of Biostatistics & Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Stephen E KimmelDepartment of Biostatistics & Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nita A LimdiDepartment of Neurology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
University of Alabama at Birmingham · USUniversity of Pennsylvania · USAlabama Department of Public Health · USEmory University · USIndiana University Bloomington · USThe University of Texas Health Science Center at Houston · USUniversity of Washington · US

Funding

UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
Predictors of hemorrhage among patients on direct acting oral anticoagulantsR01HL092173 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIMDI, NITA A · 2008 to 2023
$10.4M
UAB Center for Clinical and Translational Science (CCTS) UL1UL1TR000165 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2012 to 2013
$9.6M
PREDICTORS OF ANTICOAGULATION CONTROL ON WARFARINR01HL066176 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KIMMEL, STEPHEN E. · 2001 to 2012
$7.3M
Genome Wide Haplotype Association AnalysisR01GM081488 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIU, NIANJUN · 2008 to 2012
$1.3M
Patient Oriented Research in Personalized Antithrombotic TherapyK24HL133373 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIMDI, NITA A · 2016 to 2025
$1.2M
NCATS NIH HHS UL1 TR000165NCATS NIH HHS UL1 TR001417NHLBI NIH HHS K24 HL133373NHLBI NIH HHS R01 HL092173NIGMS NIH HHS R01 GM081488
6 · The paper itself

Abstract

aimWe conducted a genome-wide association study using the Illumina Exome Array to identify coding SNPs that may explain additional warfarin dose variability. PATIENTS &

methodsAnalysis was performed after adjustment for clinical variables and genetic factors known to influence warfarin dose among 1680 warfarin users (838 European-Americans and 842 African-Americans). Replication was performed in an independent sample.

resultsWe confirmed the influence of known genetic variants on warfarin dose variability. Our study is the first to show the association between rs12772169 and warfarin dose in African-Americans. In addition, genes COX15 and FGF5 showed significant association in European-Americans.

conclusionWe identified some novel genes/SNPs that underpin warfarin dose response. Further replication is needed to confirm our findings.

Indexed as

Pharmacogenomic VariantsPolymorphism, Single NucleotideAnticoagulantsBlack or African AmericanCytochrome P-450 CYP2C9Cytochrome P450 Family 4ExomeGenome-Wide Association StudyHumansLinkage DisequilibriumVitamin K Epoxide ReductasesWarfarinWhite PeopleAnticoagulantsCYP2C9 protein, humanCYP4F2 protein, humanCytochrome P-450 CYP2C9Cytochrome P450 Family 4Vitamin K Epoxide ReductasesVKORC1 protein, humanWarfarinCYP2C9CYP4F2exome arraygenome-wide association studyprediction modelsVKORC1warfarinwarfarin dose

Identifiers

PMID28686080
PMCPMC5619051
OpenAlexW2730291208

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.