ArticleAngewandte Chemie (International ed. in English)2017
Ruthenium-Catalyzed Azide-Thioalkyne Cycloadditions in Aqueous Media: A Mild, Orthogonal, and Biocompatible Chemical Ligation.
Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 128 citations in OpenAlex.
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- Tumor-targeted glutathione oxidation catalysis with ruthenium nanoreactors against hypoxic osteosarcoma.Nature communications · 2024Article
- Identification of mitochondrial ATP synthase as the cellular target of Ru-polypyridyl-National science review · 2024Article
- Ruthenium-catalyzed intermolecular alkene-alkyne couplings in biologically relevant media.Chemical science · 2023Article
- Versatile Synthetic Platform for 1,2,3-Triazole Chemistry.ACS omega · 2022Review
- Exporting Homogeneous Transition Metal Catalysts to Biological Habitats.European journal of organic chemistry · 2022Review
- Organometallic catalysis in aqueous and biological environments: harnessing the power of metal carbenes.Chemical science · 2022Review
- Exporting Metal-Carbene Chemistry to Live Mammalian Cells: Copper-Catalyzed Intracellular Synthesis of Quinoxalines Enabled by N-H Carbene Insertions.Angewandte Chemie (International ed. in English) · 2021Article
- In situ activation of therapeutics through bioorthogonal catalysis.Advanced drug delivery reviews · 2021Review
- Bioorthogonal Azide-Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes.Angewandte Chemie (International ed. in English) · 2021Article
- Three-Dimensional Printing of Click Functionalized, Peptide Patterned Scaffolds for Osteochondral Tissue Engineering.Bioprinting (Amsterdam, Netherlands) · 2021Article
- Cys-Cys and Cys-Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents.Angewandte Chemie (International ed. in English) · 2021Article
- The Three-Component Synthesis of 4-Sulfonyl-1,2,3-triazoles via a Sequential Aerobic Copper-Catalyzed Sulfonylation and Dimroth Cyclization.Molecules (Basel, Switzerland) · 2021Article
- DFT and AFIR study on the copper(i)-catalyzed mechanism of 5-enamine-trisubstituted-1,2,3-triazole synthesisRSC advances · 2021Article
- Intracellular Ruthenium-Promoted (2+2+2) Cycloadditions.Angewandte Chemie (International ed. in English) · 2020Article
- Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis.Nature catalysis · 2019Article
- Modular, tissue-specific, and biodegradable hydrogel cross-linkers for tissue engineering.Science advances · 2019Article
- Ruthenium-Catalyzed Redox Isomerizations inside Living Cells.Journal of the American Chemical Society · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of efficient metal-promoted bioorthogonal ligations remains as a major scientific challenge. Demonstrated herein is that azides undergo efficient and regioselective room-temperature annulations with thioalkynes in aqueous milieu when treated with catalytic amounts of a suitable ruthenium complex. The reaction is compatible with different biomolecules, and can be carried out in complex aqueous mixtures such as phosphate buffered saline, cell lysates, fetal bovine serum, and even living bacteria (E. coli). Importantly, the reaction is mutually compatible with the classical CuAAC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.