ArticleHuman brain mapping2017
The independent influences of age and education on functional brain networks and cognition in healthy older adults.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 53 citations in OpenAlex.
- Effect sizes for brain-based predictive models of cognition across the lifespan.Communications psychology · 2026Review
- Striatal network dysfunction underlying speech impairment in early Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Association between brain connectivity and renal pathophysiology: a multi-trait Mendelian randomization analysis.Brain structure & function · 2025Article
- The associations between modifiable risk factors and constipation: a comprehensive mendelian randomization study.BMC gastroenterology · 2024Article
- Differential predictability of cognitive profiles from brain structure in older males and females.GeroScience · 2024Article
- A Method to Estimate Longitudinal Change Patterns in Functional Network Connectivity of the Developing Brain Relevant to Psychiatric Problems, Cognition, and Age.Brain connectivity · 2024Article
- Multivariate patterns of brain functional connectome associated with COVID-19-related negative affect symptoms.Translational psychiatry · 2024Article
- Normative study of SATURN: a digital, self-administered, open-source cognitive assessment tool for Italians aged 50-80.Frontiers in psychology · 2024Article
- High Homocysteine Levels Are Associated with Cognitive Impairment in Patients Who Recovered from COVID-19 in the Long Term.Journal of personalized medicine · 2023Article
- Article
- State-switching and high-order spatiotemporal organization of dynamic functional connectivity are disrupted by Alzheimer's disease.Network neuroscience (Cambridge, Mass.) · 2023Article
- Interrelating differences in structural and functional connectivity in the older adult's brain.Human brain mapping · 2022Article
- The impacts of HIV infection, age, and education on functional brain networks in adults with HIV.Journal of neurovirology · 2022Article
- Heterogeneous nuclear ribonucleoprotein A2/B1 as a novel biomarker in elderly patients for the prediction of postoperative neurocognitive dysfunction: A prospective nested case-control study.Frontiers in aging neuroscience · 2022Article
- Age-Dependent Association Between Cognitive Reserve Proxy and Longitudinal White Matter Microstructure in Older Adults.Frontiers in psychology · 2022Article
- Association of Lifestyle Activities with Functional Brain Connectivity and Relationship to Cognitive Decline among Older Adults.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Distributed functional connectivity predicts neuropsychological test performance among older adults.Human brain mapping · 2021Article
- Stability test of canonical correlation analysis for studying brain-behavior relationships: The effects of subject-to-variable ratios and correlation strengths.Human brain mapping · 2021Article
- Resting-state networks in the course of aging-differential insights from studies across the lifespan vs. amongst the old.Pflugers Archiv : European journal of physiology · 2021Review
- APOE ε4 and cognitive reserve effects on the functional network in the Alzheimer's disease spectrum.Brain imaging and behavior · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Healthy aging is accompanied by a constellation of changes in cognitive processes and alterations in functional brain networks. The relationships between brain networks and cognition during aging in later life are moderated by demographic and environmental factors, such as prior education, in a poorly understood manner. Using multivariate analyses, we identified three latent patterns (or modes) linking resting-state functional connectivity to demographic and cognitive measures in 101 cognitively normal elders. The first mode (P = 0.00043) captures an opposing association between age and core cognitive processes such as attention and processing speed on functional connectivity patterns. The functional subnetwork expressed by this mode links bilateral sensorimotor and visual regions through key areas such as the parietal operculum. A strong, independent association between years of education and functional connectivity loads onto a second mode (P = 0.012), characterized by the involvement of key hub regions. A third mode (P = 0.041) captures weak, residual brain-behavior relations. Our findings suggest that circuits supporting lower level cognitive processes are most sensitive to the influence of age in healthy older adults. Education, and to a lesser extent, executive functions, load independently onto functional networks-suggesting that the moderating effect of education acts upon networks distinct from those vulnerable with aging. This has important implications in understanding the contribution of education to cognitive reserve during healthy aging. Hum Brain Mapp 38:5094-5114, 2017. © 2017 Wiley Periodicals, Inc.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.