ArticleEvolution; international journal of organic evolution2017
The evolution of phenotypic integration: How directional selection reshapes covariation in mice.
Article in Evolution; international journal of organic evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Evolution of Phenotypic Variance Provides Insights into the Genetic Basis of Adaptation.Genome biology and evolution · 2024Article
- Article
- Evolution of the locomotor skeleton in Anolis lizards reflects the interplay between ecological opportunity and phylogenetic inertia.Nature communications · 2021Article
- Article
- Long-term research and hierarchical models reveal consistent fitness costs of being the last egg in a clutch.The Journal of animal ecology · 2020Article
- Measuring the magnitude of morphological integration: The effect of differences in morphometric representations and the inclusion of size.Evolution; international journal of organic evolution · 2019Article
- Development of G: a test in an amphibious fish.Heredity · 2019Article
- Morphological variation under domestication: how variable are chickens?Royal Society open science · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Variation is the basis for evolution, and understanding how variation can evolve is a central question in biology. In complex phenotypes, covariation plays an even more important role, as genetic associations between traits can bias and alter evolutionary change. Covariation can be shaped by complex interactions between loci, and this genetic architecture can also change during evolution. In this article, we analyzed mouse lines experimentally selected for changes in size to address the question of how multivariate covariation changes under directional selection, as well as to identify the consequences of these changes to evolution. Selected lines showed a clear restructuring of covariation in their cranium and, instead of depleting their size variation, these lines increased their magnitude of integration and the proportion of variation associated with the direction of selection. This result is compatible with recent theoretical works on the evolution of covariation that take the complexities of genetic architecture into account. This result also contradicts the traditional view of the effects of selection on available covariation and suggests a much more complex view of how populations respond to selection.
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Registered trials
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