ArticleNature communications2017
MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 130 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
130 citing papers in PubMed, 1 synthesis or guideline pooled it, 204 citations in OpenAlex.
- Pooled it
- Vascular-lymphatic dual circulation in bone health and disease: Mechanistic coupling and translational therapeutics.Journal of orthopaedic translation · 2026Review
- Machine Learning-Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Bidirectional integrin β1 activation synergizes neurovascular coupling and enhances bone regeneration.Nature communications · 2026Article
- Vascular and musculoskeletal interactions: structure, function, and therapeutic strategies for sarcopenia and osteoporosis.MedScience · 2026Review
- Mechanism of HIF-1α-mediated angiogenesis in rheumatoid arthritis and progress of natural medicine interventions.Frontiers in pharmacology · 2026Review
- Research Hotspots and Emerging Trends in Osteoporosis Epigenetics.Genetics research · 2026Article
- Unlocking bone repair in osteoporosis by targeting the angiogenic niche.Frontiers in endocrinology · 2026Review
- Selenium-Doped Calcium Hydroxide Nanoparticles Inhibit Osteoclasts and Promote Osteogenesis for Osteoporosis Treatment.International journal of nanomedicine · 2026Article
- Endothelial cell-targeting aptamer-empowered exosomes accelerate wound healing by promoting specialized angiogenesis in type 1 diabetic mice.Stem cell research & therapy · 2025Article
- Mechanical energy-charged navigating pump repair natural vascular scaffolds to reverse osteoporosis.Materials today. Bio · 2025Article
- Optimizing type H vessels formationBioactive materials · 2025Article
- The Mechanism and Potential Therapeutic Strategies of Vascular Aging.Aging medicine (Milton (N.S.W)) · 2025Review
- Nucleic acid aptamers in orthopedic diseases: promising therapeutic agents for bone disorders.Bone research · 2025Review
- Cell communication and relevant signaling pathways in osteogenesis-angiogenesis coupling.Bone research · 2025Review
- Metformin ameliorates osteoporosis by enhancing bone angiogenesis via the YAP1/TAZ-HIF1α axis.Molecular medicine (Cambridge, Mass.) · 2025Article
- mpECs with high Piezo2 expression promote fracture healing by driving angiogenesis through the Notch signaling pathway.BMC musculoskeletal disorders · 2025Article
- CUL1 exacerbates glucocorticoid-induced osteoporosis by enhancing ASAP1 ubiquitination.Hormones (Athens, Greece) · 2025Article
- Piezo1 promotes vibration-induced vascular smooth muscle injury by regulating the NF-κB/p65 axis.Communications biology · 2025Article
- Non-coding RNAs in osteoarthritis and osteoporosis-related hip fractures: molecular biomarkers for precision diagnosis and prognosis.Frontiers in endocrinology · 2025Review
70 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 4 institutions in 2 countries.
Mi YangDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Chang-Jun LiDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Xi SunDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Qi GuoDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Ye XiaoDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Tian SuDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Man-Li TuDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Hui PengDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Qiong LuDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Qing LiuDepartment of Orthopedic Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Hong-Bo HeDepartment of Orthopedic Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Tie-Jian JiangDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Min-Xiang LeiDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Mei WanDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Xu CaoDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Xiang-Hang LuoDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Central South University · CNXiangya Hospital Central South University · CNJohns Hopkins University · USJohns Hopkins Medicine · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
A specific bone vessel subtype, strongly positive for CD31 and endomucin (CD31
Indexed as
AnimalsAntagomirsAptamers, NucleotideBone and BonesBone DensityF-Box-WD Repeat-Containing Protein 7Gene Expression Regulation, DevelopmentalHumansHypoxia-Inducible Factor 1, alpha SubunitMiceMice, KnockoutMicroRNAsMolecular Targeted TherapyNeovascularization, PhysiologicOsteogenesisOsteoporosisAntagomirsAptamers, NucleotideEmcn protein, mouseF-Box-WD Repeat-Containing Protein 7Fbxw7 protein, mouseHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitMicroRNAsmirn497 microRNA, mouseNotch1 protein, mousePecam1 protein, mousePlatelet Endothelial Cell Adhesion Molecule-1Prolyl HydroxylasesReceptor, Notch1Sialoglycoproteins
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.