Evidence map›Paper›PMID 28685424›Full record

ReviewAdvances in experimental medicine and biology2017

Factors Determining the Oxygen Permeability of Biological Membranes: Oxygen Transport Across Eye Lens Fiber-Cell Plasma Membranes.

Witold Karol Subczynski, Justyna Widomska, Laxman Mainali

Open access · greenAbstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Witold Karol SubczynskiDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA. subczyn@mcw.edu.
Justyna WidomskaDepartment of Biophysics, Medical University of Lublin, Lublin, Poland.
Laxman MainaliDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.
Medical College of Wisconsin · USMedical University of Lublin · PL

Funding

TR&D Project 3P41EB001980 · NIBIB · MEDICAL COLLEGE OF WISCONSIN · PI KLUG, CANDICE S · 2003 to 2017
$16.3M
MORPHOLOGY MODULEP30EY001931 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI LINK, BRIAN A · 1985 to 2016
$9.8M
DEVELOPMENT OF BIOMEDICAL ESR INSTRUMENTATIONR01EB002052 · NIBIB · MEDICAL COLLEGE OF WISCONSIN · PI KLUG, CANDICE S · 2003 to 2015
$6.4M
Liquid Rafts in Eye Lens: Discrimination by Pulse EPRR01EY015526 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI SUBCZYNSKI, WITOLD K · 2005 to 2019
$4.8M
NEI NIH HHS P30 EY001931NEI NIH HHS R01 EY015526NIBIB NIH HHS P41 EB001980NIBIB NIH HHS R01 EB002052NIH HHS EB002052NIH HHS EY001931NIH HHS EY015526
6 · The paper itself

Abstract

Electron paramagnetic resonance (EPR) spin-label oximetry allows the oxygen permeability coefficient to be evaluated across homogeneous lipid bilayer membranes and, in some cases, across coexisting membrane domains without their physical separation. The most pronounced effect on oxygen permeability is observed for cholesterol, which additionally induces the formation of membrane domains. In intact biological membranes, integral proteins induce the formation of boundary and trapped lipid domains with a low oxygen permeability. The effective oxygen permeability coefficient across the intact biological membrane is affected not only by the oxygen permeability coefficients evaluated for each lipid domain but also by the surface area occupied by these domains in the membrane. All these factors observed in fiber cell plasma membranes of clear human eye lenses are reviewed here.

Indexed as

Cell Membrane PermeabilityBiological TransportCell MembraneElectron Spin Resonance SpectroscopyHumansLens, CrystallineLipid BilayersMembrane LipidsOptic NerveOxygenPermeabilityLipid BilayersMembrane LipidsOxygenBiological membranesCholesterolModel membranesOxygenPermeability

Identifiers

PMID28685424
PMCPMC5851008
OpenAlexW2727982157

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.