ReviewMolecular and cellular pediatrics2017
The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO)-a systematic review.
Review in Molecular and cellular pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- Pamidronate for pain in adult chronic nonbacterial osteitis: protocol of a randomized, double-blind, placebo-controlled trial.JBMR plus · 2024Trial
- Chronic non-bacterial osteomyelitis presenting as fever of unknown origin in a child: a diagnostic pitfall.BMC pediatrics · 2026Article
- [Chronic nonbacterial osteomyelitis/osteitis of childhood and adolescence].Zeitschrift fur Rheumatologie · 2026Review
- Evaluating the osteoclastogenic potential of peripheral blood mononuclear cells in children with chronic nonbacterial osteomyelitis.JBMR plus · 2026Article
- Transient osteoporosis of the hip in a 17-year-old nonpregnant female: a case report.Journal of medical case reports · 2025Article
- Update on the diagnosis and treatment of CNO in children: a clinician's perspective.European journal of pediatrics · 2024Review
- Immunological Characterization of Chronic Nonbacterial Osteomyelitis (CNO) in Adults: A Cross-Sectional Exploratory Study.JBMR plus · 2023Article
- Priorities in Chronic nonbacterial osteomyelitis (CNO) - results from an international survey and roundtable discussions.Pediatric rheumatology online journal · 2023Article
- Cachexia, chorea, and pain in chronic nonbacterial osteitis and inflammatory bowel disease: a case report.Journal of medical case reports · 2023Article
- Case report: Child chronic nonbacterial osteomyelitis with rapid progressive scoliosis-an association with disease?Frontiers in pediatrics · 2023Article
- Chronic nonbacterial monoarticular osteomyelitis of the elbow.JSES reviews, reports, and techniques · 2022Article
- Chronic nonbacterial osteomyelitis in children: a multicentre Belgian cohort of 30 children.Pediatric rheumatology online journal · 2022Article
- Whole-body magnetic resonance imaging findings and patterns of chronic nonbacterial osteomyelitis in a series of Greek pediatric patients.Acta radiologica open · 2022Article
- Patient-reported effectiveness and safety of Pamidronate in NSAIDs-refractory chronic recurrent multifocal osteomyelitis in children.Rheumatology international · 2022Article
- Chronic recurrent multifocal osteomyelitis. A narrative and pictorial review.Frontiers in immunology · 2022Review
- Assessment of disease activity using a whole-body MRI derived radiological activity index in chronic nonbacterial osteomyelitis.Pediatric rheumatology online journal · 2021Article
- Chronic Nonbacterial Osteomyelitis in Children.Children (Basel, Switzerland) · 2021Review
- Article
- Chronic Nonbacterial Osteomyelitis of the Sternocostoclavicular Region in Adults: A Single-Center Dutch Cohort Study.JBMR plus · 2021Article
- Majeed Syndrome: A Review of the Clinical, Genetic and Immunologic Features.Biomolecules · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic non-bacterial osteomyelitis (CNO) belongs to the growing spectrum of autoinflammatory diseases and primarily affects the skeletal system. Peak onset ranges between 7 and 12 years of age. The clinical spectrum of CNO covers sometimes asymptomatic inflammation of single bones at the one end and chronically active or recurrent multifocal osteitis at the other.Despite the intense scientific efforts, the exact molecular mechanisms of CNO remain unknown. Recent data suggest CNO as a genetically complex disorder with dysregulated TLR4/MAPK/inflammasome signaling cascades resulting in an imbalance between pro- and anti-inflammatory cytokine expression, leading to osteoclast activation and osteolytic lesions.In this manuscript, the current understanding of molecular patho-mechanisms in CNO will be discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.