ArticleMolecular biology reports2017
Genetic risk factors for myocardial infarction more clearly manifest for early age of first onset.
Article in Molecular biology reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 14 citations in OpenAlex.
- Effects of familial hypercholesterolemia-associated genes on the phenotype of premature myocardial infarction.Lipids in health and disease · 2019Trial
- Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction.Lipids in health and disease · 2021Article
- Expression of TLR4-PTGE2 signaling genes in atherosclerotic carotid plaques and peripheral blood.Molecular biology reports · 2019Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Epidemiological genetics established that heritability in determining the risk of myocardial infarction (MI) is substantially greater when MI occurs early in life. However, the genetic architecture of early-onset and late-onset MI was not compared. We analyzed genotype frequencies of SNPs in/near 20 genes whose protein products are involved in the pathogenesis of atherosclerosis in two groups of Russian patients with MI: the first group included patients with age of first MI onset <60 years (N = 230) and the second group with onset ≥60 years (N = 174). The control group of corresponding ethnicity consisted of 193 unrelated volunteers without cardiovascular diseases (93 individuals were over 60 years). We found that in the group of patients with age of onset <60 years, SNPs FGB rs1800788*T, TGFB1 rs1982073*T/T, ENOS rs2070744*C and CRP rs1130864*T/T were associated with risk of MI, whereas in patients with age of onset ≥60 years, only TGFB1 rs1982073*T/T was associated with risk of MI. Using APSampler software, we found composite markers associated with MI only in patients with early onset: FGB rs1800788*T + TGFB1 rs1982073*T; FGB rs1800788*T + LPL rs328*C + IL4 rs2243250*C; FGB rs1800788*T + ENOS rs2070744*C (Fisher p values of 1.4 × 10
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