Evidence map›Paper›PMID 28685234›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2017

Prostanoid EP3 receptor agonist sulprostone enhances pacemaker activity of colonic interstitial cells of Cajal.

Man Woo Kim, Han Yi Jiao, Seok Won Kim, Chan Guk Park, Mei Jin Wu, Chansik Hong, Seok Choi, Jae Yeoul Jun

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Acid increases PGEJournal of clinical biochemistry and nutrition · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Man Woo KimDepartment of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea.
Han Yi JiaoDepartment of Physiology, College of Medicine, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju, 501-375, South Korea.
Seok Won KimDepartment of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea.
Chan Guk ParkDepartment of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea.
Mei Jin WuDepartment of Physiology, College of Medicine, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju, 501-375, South Korea.
Chansik HongDepartment of Physiology, College of Medicine, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju, 501-375, South Korea.
Seok ChoiDepartment of Physiology, College of Medicine, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju, 501-375, South Korea.
Jae Yeoul JunDepartment of Physiology, College of Medicine, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju, 501-375, South Korea. jyjun@chosun.ac.kr.
Chosun University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

EP receptor activation by PGE2 regulates gastrointestinal motility by modulating smooth muscle contractility. Interstitial cells of Cajal (ICCs) are pacemaker cells that regulate smooth muscle activity. We aimed to determine effects of the EP3 receptor agonist sulprostone on pacemaker potentials in colonic ICCs. We performed a whole cell patch clamp, RT-PCR, and Ca

Indexed as

AnimalsAnoctamin-1CalciumCells, CulturedColonDinoprostoneEndoplasmic ReticulumFemaleGastrointestinal MotilityHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsInterstitial Cells of CajalMaleMiceMice, Inbred BALB CMuscle ContractionMuscle, SmoothANO1 protein, mouseAnoctamin-1CalciumDinoprostoneHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsReceptors, Prostaglandin E, EP3 SubtypesulprostoneColonic motilityHyperpolarization-activated cyclic nucleotide-gated channelInterstitial cells of CajalPacemaker activityProstanoid EP3 receptorSulprostone

Identifiers

PMID28685234
OpenAlexW2731310575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.