Evidence map›Paper›PMID 28685222›Full record

ArticleVirus genes2017

Characterization of Eptesipoxvirus, a novel poxvirus from a microchiropteran bat.

Shin-Lin Tu, Yoshinori Nakazawa, Jinxin Gao, Kimberly Wilkins, Nadia Gallardo-Romero, Yu Li, Ginny L Emerson, Darin S Carroll, Chris Upton

Open access · greenAbstract read
In one paragraph

Article in Virus genes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Shin-Lin TuDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
Yoshinori NakazawaThe National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention, Atlanta, GA, USA.
Jinxin GaoThe National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention, Atlanta, GA, USA.
Kimberly WilkinsThe National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention, Atlanta, GA, USA.
Nadia Gallardo-RomeroThe National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention, Atlanta, GA, USA.
Yu LiThe National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention, Atlanta, GA, USA.
Ginny L EmersonThe National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention, Atlanta, GA, USA.
Darin S CarrollThe National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention, Atlanta, GA, USA.
Chris UptonDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada. cupton@uvic.ca.ORCID http://orcid.org/0000-0002-9019-8967
Centers for Disease Control and Prevention · USUniversity of Victoria · CA

Funding

Intramural CDC HHS CC999999NSERC 04953
6 · The paper itself

Abstract

The genome of Eptesipoxvirus (EPTV) is the first poxvirus genome isolated from a microbat. The 176,688 nt sequence, which is believed to encompass the complete coding region of the virus, is 67% A+T and is predicted to encode 191 genes. 11 of these genes have no counterpart in GenBank and are therefore unique to EPTV. The presence of a distantly related ortholog of Vaccinia virus F5L in EPTV uncovered a link with fragmented F5L orthologs in Molluscum contagiosum virus/squirrelpox and clade II viruses. Consistent with the unique position of EPTV approximately mid-point between the orthopoxviruses and the clade II viruses, EPTV has 11 genes that are specific to the orthopoxviruses and 13 genes that are typical, if not exclusive, to the clade II poxviruses. This mosaic nature of EPTV blurs the distinction between the old description of the orthopoxvirus and clade II groups. Genome annotation and characterization failed to find any common virulence genes shared with the other poxvirus isolated from bat (pteropoxvirus); however, EPTV encodes 3 genes that may have been transferred to or from deerpox and squirrelpox viruses; 2 of these, a putative endothelin-like protein and a MHC class I-like protein are likely to have immunomodulatory roles.

Indexed as

AnimalsChiropteraDNA, ViralGenome, ViralMolecular Sequence AnnotationOrthopoxvirusPoxviridaeVaccinia virusViral ProteinsVirulenceDNA, ViralViral ProteinsBatpoxEptesipoxvirusNext-generation sequencingNGSPoxvirus

Identifiers

PMID28685222
PMCPMC6504846
OpenAlexW2726551565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.