Evidence map›Paper›PMID 28685207›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2017

Clinical effects of long-term cardiac contractility modulation (CCM) in subjects with heart failure caused by left ventricular systolic dysfunction.

D Müller, A Remppis, P Schauerte, S Schmidt-Schweda, D Burkhoff, B Rousso, D Gutterman, J Senges, G Hindricks, K-H Kuck

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Long-term effects of device-guided slow breathing in stable heart failure patients with reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2019
    Trial
  4. Noninvasive pulse contour analysis for determination of cardiac output in patients with chronic heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2018
    Trial
  5. Review
  6. Review
  7. Article
  8. Beyond Medical Therapy-An Update on Heart Failure Devices.Journal of cardiovascular development and disease · 2024
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Similarities and Differences Between HFmrEF and HFpEF.Frontiers in cardiovascular medicine · 2021
    Review
  17. Review
  18. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

D MüllerHeart and Vascular Center (HGZ), Bad Bevensen, Germany.ORCID http://orcid.org/0000-0003-2814-7867
A RemppisHeart and Vascular Center (HGZ), Bad Bevensen, Germany. ba.remppis@hgz-bb.de.
P SchauerteUniversity Hospital Aachen RWTH, Berlin, Germany.
S Schmidt-SchwedaGeorg August University of Gottingen, Gottingen, Germany.
D BurkhoffColumbia University, New York, NY, USA.
B RoussoImpulse Dynamics, Hod Hasharon, Israel.
D GuttermanMedical College of Wisconsin, Milwaukee, WI, USA.
J SengesInstitut für Herzinfarktforschung, Ludwigshafen, Germany.
G HindricksHeart Center Leipzig, Leipzig, Germany.
K-H KuckAsklepios Klinik St. Georg, Hamburg, Germany.
Klinik Lüneburger Heide · DEAsklepios Klinik St. Georg · DEColumbia University · USLeipzig Heart Institute · DEMedical College of Wisconsin · USStiftung Institut für Herzinfarktforschung · DEUniversitätsklinikum Aachen · DEUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHeart failure is a major cause of morbidity and mortality throughout the world. Despite advances in therapy, nearly half of patients receiving guideline-directed medical therapy remain limited by symptoms. Cardiac contractility modulation (CCM) can improve symptoms in this population, but efficacy and safety in prospective studies has been limited to 12 months of follow-up. We report on the first 2 year multi-site evaluation of CCM in patients with heart failure.

methodsOne hundred and forty-three subjects with heart failure and reduced ejection fraction were followed via clinical registry for 24 months recording NYHA class, MLWHFQ score, 6 min walk distance, LVEF, and peak VO

resultsOne hundred and six subjects from 24 sites completed the 24 month follow-up. Baseline parameters were similar among LVEF groups. NYHA and MLWHFQ improved in all 3 groups at each time point. LVEF in the entire cohort improved 2.5, 2.9, 5.0, and 4.9% at 6, 12, 18, and 24 months, respectively. Insufficient numbers of subjects had follow-up data for 6 min walk or peak VO

conclusionCardiac contractility modulation provides safe and effective long-term symptomatic and functional improvement in heart failure. These benefits were independent of baseline LVEF and were associated with a safety profile similar to published device trials.

Indexed as

Cardiac Pacing, ArtificialExercise ToleranceAgedCause of DeathFemaleFollow-Up StudiesGermanyHeart FailureHumansIsraelMaleMiddle AgedMyocardial ContractionProspective StudiesQuality of LifeStroke VolumeCCMClinicalElectrical stimulationHeart failureHumanLVEFMLWHFQNYHARegistrySurvival

Identifiers

PMID28685207
PMCPMC5655601
OpenAlexW2725526541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.