ArticleNPJ systems biology and applications2017
Integrative analysis of pathway deregulation in obesity.
Article in NPJ systems biology and applications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The novel adipokine Placin regulates glucose homeostasis via insulin secretion and IGF1 receptor signaling.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Quantitative analysis of disease-related metabolic dysregulation of human microbiota.iScience · 2023Article
- Artificial intelligence in breast cancer diagnostics.Cell reports. Medicine · 2022Article
- Classification of triple negative breast cancer by epithelial mesenchymal transition and the tumor immune microenvironment.Scientific reports · 2022Article
- Article
- Diversity and molecular network patterns of symptom phenotypes.NPJ systems biology and applications · 2021Article
- Transcriptome analysis reveals the difference between "healthy" and "common" aging and their connection with age-related diseases.Aging cell · 2020Article
- The potential role of leptin in tumor invasion and metastasis.Cytokine & growth factor reviews · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Obesity is a pandemic disease, linked to the onset of type 2 diabetes and cancer. Transcriptomic data provides a picture of the alterations in regulatory and metabolic activities associated with obesity, but its interpretation is typically blurred by noise. Here, we solve this problem by collecting publicly available transcriptomic data from adipocytes and removing batch effects using singular value decomposition. In this way we obtain a gene expression signature of 38 genes associated to obesity and identify the main pathways involved. We then show that similar deregulation patterns can be detected in peripheral markers, in type 2 diabetes and in breast cancer. The integration of different data sets combined with the study of pathway deregulation allows us to obtain a more complete picture of gene-expression patterns associated with obesity, breast cancer, and diabetes.
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Registered trials
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