ReviewBeilstein journal of organic chemistry2017
Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic.
Review in Beilstein journal of organic chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Article
- Leveraging Metal and Ligand Reactive Sites for One Pot Reactions: Ligand-Centered Borenium Ions for Tandem Catalysis with Palladium.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Reaching New Biocatalytic Reactivity Using Continuous Flow Reactors.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Review
- "Green Is the Color": An Update on Ecofriendly Aspects of Organoselenium Chemistry.Molecules (Basel, Switzerland) · 2022Review
- Digital Transformation in Materials Science: A Paradigm Change in Material's Development.Advanced materials (Deerfield Beach, Fla.) · 2021Review
- Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds.International journal of molecular sciences · 2021Review
- The Medicinal Chemistry in the Era of Machines and Automation: Recent Advances in Continuous Flow Technology.Journal of medicinal chemistry · 2020Review
- The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.Angewandte Chemie (International ed. in English) · 2018Review
- Assessing the possibilities of designing a unified multistep continuous flow synthesis platform.Beilstein journal of organic chemistry · 2018Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The implementation of automation in the multistep flow synthesis is essential for transforming laboratory-scale chemistry into a reliable industrial process. In this review, we briefly introduce the role of automation based on its application in synthesis viz. auto sampling and inline monitoring, optimization and process control. Subsequently, we have critically reviewed a few multistep flow synthesis and suggested a possible control strategy to be implemented so that it helps to reliably transfer the laboratory-scale synthesis strategy to a pilot scale at its optimum conditions. Due to the vast literature in multistep synthesis, we have classified the literature and have identified the case studies based on few criteria viz. type of reaction, heating methods, processes involving in-line separation units, telescopic synthesis, processes involving in-line quenching and process with the smallest time scale of operation. This classification will cover the broader range in the multistep synthesis literature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.