Evidence map›Paper›PMID 28684957›Full record

ArticleEpilepsy currents

Practice Guideline Summary: Sudden Unexpected Death in Epilepsy Incidence Rates and Risk Factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society.

Cynthia Harden, Torbjörn Tomson, David Gloss, Jeffrey Buchhalter, J Helen Cross, Elizabeth Donner, Jacqueline A French, Anthony Gil-Nagel, Dale C Hesdorffer, W Henry Smithson and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy currents. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 161 citations in OpenAlex.

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  8. Holistic management of epilepsy in adults with intellectual development disorders.Epileptic disorders : international epilepsy journal with videotape · 2026
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 14 institutions in 8 countries.

Cynthia HardenDepartment of Neurology, Mount Sinai Health System, New York, NY.
Torbjörn TomsonDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
David GlossDepartment of Neurology, CAMC Physicians, Charleston, WV.
Jeffrey BuchhalterAlberta Children's Hospital, Departments of Pediatrics and Clinical Neurosciences, University of Calgary, Calgary, Canada.
J Helen CrossDepartment of Clinical Neurosciences, University College London - Institute of Child Health, and Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.
Elizabeth DonnerDivision of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Jacqueline A FrenchDepartment of Neurology, New York University Langone Comprehensive Epilepsy Center, New York, NY.
Anthony Gil-NagelDepartment of Neurology, Hospital Ruber Internacional, Madrid, Spain.
Dale C HesdorfferGertrude H. Sergievsky Center and Department of Epidemiology, Columbia University Medical Center, New York, NY.
W Henry SmithsonDepartment of General Practice, University College Cork, Cork, Ireland.
Mark C SpitzAnschutz Outpatient Pavilion, University of Colorado Health, Aurora, CO.
Thaddeus S WalczakNeurology Clinic, University of Minnesota, Minneapolis, MN.
Josemir W SanderUniversity College London Institute of Neurology, London, United Kingdom, and Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands.
Philippe RyvlinDepartment of Clinical Neurosciences, CHUV, Lausanne, Switzerland.
Alberta Children's Hospital · CACAMC Health Education and Research Institute · USColumbia University Irving Medical Center · USHospital for Sick Children · CAHospital Ruber Internacional · ESKarolinska Institutet · SEMount Sinai Health System · USNYU Langone Health · USStichting Epilepsie Instellingen Nederland · NLUniversity College Cork · IEUniversity College London · GBUniversity Hospital of Lausanne · CHUniversity of Colorado Health · USUniversity of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the incidence rates of sudden unexpected death in epilepsy (SUDEP) in different epilepsy populations and address the question of whether risk factors for SUDEP have been identified.

methodsSystematic review of evidence; modified Grading Recommendations Assessment, Development and Evaluation process for developing conclusions; recommendations developed by consensus.

resultsFindings for incidence rates based on 12 Class I studies include the following: SUDEP risk in children with epilepsy (aged 0-17 years) is 0.22/1,000 patient-years (95% CI 0.16-0.31) (high confidence in evidence). SUDEP risk increases in adults to 1.2/1,000 patient-years (95% CI 0.64-2.32) (low confidence in evidence). The major risk factor for SUDEP is the occurrence of generalized tonic-clonic seizures (GTCS); the SUDEP risk increases in association with increasing frequency of GTCS occurrence (high confidence in evidence). RECOMMENDATIONS: Level B: Clinicians caring for young children with epilepsy

Identifiers

PMID28684957
PMCPMC5486432
OpenAlexW4249265228

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.